{
  "abstract": "In Arabidopsis (Arabidopsis thaliana) roots, growth initiation and cessation are organized into distinct zones. How regulatory mechanisms are integrated to coordinate these processes and maintain proper growth progression over time remains poorly understood. Here, we demonstrate that the peptide hormone PLANT PEPTIDE CONTAINING SULFATED TYROSINE 1 (PSY1) promotes root growth by controlling cell elongation. Higher levels of PSY1 lead to longer differentiated cells with a shootward displacement of characteristics common to mature cells. PSY1 activates genes involved in the biosynthesis of flavonols, a group of plant-specific specialized metabolites. Consistent with these transcriptional changes, metabolomic analysis reveals an enrichment of diverse flavonol glycosides upon PSY1 treatment. Using genetic and chemical approaches, we show that PSY1-mediated flavonol accumulation is localized to the differentiation zone and is required for PSY1 function. PSY1 signaling in this zone is associated with a reduction of hydrogen peroxide accumulation and a decrease in auxin-induced gene expression. These findings support a model where PSY1 signals the developmental-specific accumulation of specialized metabolites to regulate the extent of cell elongation and progression to maturation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Plant Pathology, University of California , Davis, CA 95616, United States",
    "The Genome Center, University of California , Davis, CA 95616, United States",
    "The Innovative Genomics Institute, University of California , Berkeley, CA 94720 , United States",
    "Joint BioEnergy Institute DOE , Emeryville, CA 94608 , United States",
    "Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States",
    "Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory , Berkeley, CA 94720 , United States"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "María Florencia Ercoli",
      "orcid": "0000-0001-5587-6227"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexandra M. Shigenaga",
      "orcid": "0000-0001-8649-2891"
    },
    {
      "affs": [
        0,
        3,
        1
      ],
      "name": "Artur Teixeira de Araújo",
      "orcid": "0000-0002-5155-8755"
    },
    {
      "affs": [
        4
      ],
      "name": "Katherine Louie",
      "orcid": "0000-0002-6787-7558"
    },
    {
      "affs": [
        5,
        4
      ],
      "name": "Benjamin P. Bowen",
      "orcid": "0000-0003-1368-3958"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tracy Satomi Weitz",
      "orcid": "0009-0000-4936-6028"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sangeetha Ramesh",
      "orcid": "0000-0002-9229-2009"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rashmi Jain",
      "orcid": "0000-0001-6819-847X"
    },
    {
      "affs": [
        5,
        4
      ],
      "name": "Trent R. Northen",
      "orcid": "0000-0001-8404-3259"
    },
    {
      "affs": [
        0,
        3,
        1,
        2
      ],
      "name": "Pamela C. Ronald",
      "orcid": "0000-0002-4107-1345"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7nmxt8h1v0tzk.bib",
  "cited_by": 7,
  "doi": "10.1093/plcell/koag180",
  "fulltext_url": null,
  "id": "7nmxt8h1v0tzk",
  "issns": [
    "1040-4651",
    "1532-298X"
  ],
  "landing_url": "https://doi.org/10.1093/plcell/koag180",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant Molecular Biology Research"
    ]
  ],
  "openalex": "W7164905808",
  "pdf_url": null,
  "pmcid": "PMC10862922",
  "pmid": "38352507",
  "published": "2026-06-16",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/7nmxt8h1v0tzk.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:08Z",
      "native_id": "W7164905808",
      "source": "openalex",
      "url": "https://doi.org/10.1093/plcell/koag180"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Molecular Biology Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root",
  "title_text": "Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:08Z",
  "url": "https://research.draconitic.com/paper/7nmxt8h1v0tzk",
  "venue": "The Plant Cell",
  "versions": []
}