{
  "abstract": "Root system architecture plasticity is critical for optimizing anchorage and nutrient and water uptake. However, whether and how biogenic molecular hydrogen (H₂) influences root plasticity remains further explored. Here, using ABA-inhibited plant root growth as a research model, we show that Arabidopsis hydrogenase Nuclear Architecture Related 1 (NAR1)-dependent H₂ reshapes root plasticity. First, we observed that NAR1 overexpression promotes primary root elongation and meristem cell division, whereas RNAi-NAR1 lines show impaired root growth, particularly upon ABA administration. Consistently, ABA-inhibited CYCB1;1 expression, a G2/M marker, was substantially recovered or aggravated in OE-NAR1 or RNAi-NAR1 lines. Further analysis revealed that NAR1 preserves DR5 activity, and AUX1, PIN1, and PIN2 signals under ABA. In parallel, NAR1 sustains cellular homeostasis by limiting ABA-triggered oxidative stress, as evidenced by upregulation of antioxidant defense and reduced ROS and lipid peroxidation. The functional requirement for NAR1-derived H₂ was further corroborated by H₂ supplementation, which effectively rescued the inhibited phenotypes of RNAi-NAR1 lines. Together, our findings reveal a convergence of meristem cell division activity, auxin signaling and ROS homeostasis governed by NAR1-dependent H₂, which reshapes root plasticity under ABA treatment. These observations provide new molecular insights into endogenous H₂ signaling for shaping plant plasticity in complex environments.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory Center of Life Sciences, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.",
    "School of Design, Shanghai Jiao Tong University, Shanghai 200240, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ke Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Pengfei Cheng",
      "orcid": "0009-0009-1495-6533"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziyu Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongmei Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenbiao Shen",
      "orcid": "0000-0003-1525-9472"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7np5veb4vq9pv.bib",
  "cited_by": 0,
  "doi": "10.3390/antiox15101228",
  "fulltext_url": "https://europepmc.org/articles/PMC13700628",
  "id": "7np5veb4vq9pv",
  "issns": [
    "2076-3921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42939802",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant Molecular Biology Research"
    ]
  ],
  "openalex": "W7214094811",
  "pdf_url": "https://europepmc.org/articles/PMC13700628?pdf=render",
  "pmcid": "PMC13700628",
  "pmid": "42939802",
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7np5veb4vq9pv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42939802",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42939802"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Molecular Biology Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "Nuclear Architecture Related 1-Dependent H₂ Reshapes Root Plasticity Through Targeting Root Meristem Cell Division Activity.",
  "title_text": "Nuclear Architecture Related 1-Dependent H₂ Reshapes Root Plasticity Through Targeting Root Meristem Cell Division Activity.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/7np5veb4vq9pv",
  "venue": "Antioxidants (Basel, Switzerland)",
  "versions": []
}