{
  "abstract": "Current chemotherapy options for lung cancer (LC) are limited by poor tumor selectivity, systemic toxicity, and acquired resistance. Photodynamic therapy (PDT) offers a promising minimally invasive modality as a potential conservative or complementary approach, yet its clinical adoption has been constrained by suboptimal photosensitizers and unclear mechanisms. This study investigated a novel PDT regimen combining a 450 nm blue laser with the photosensitizer sinoporphyrin sodium (DVDMS) to address these limitations in LC. Our findings demonstrate that BL-DVDMS treatment selectively inhibits lung cancer cell proliferation while sparing normal bronchial epithelial cells. Low-dose PDT induces a moderate oxidative stress response, leading to DNA damage and G2/M cell cycle arrest. Importantly, this treatment triggers a senescence-associated phenotype, evidenced by increased SA-β-Gal activity and elevated secretion of SASP factors (IL-6, IL-8), accompanied by altered p53/GADD45 A signaling. These effects are abrogated by ROS scavenging or p53 inhibition, indicating that the oxidative response plays a central role in the observed antitumor activity. In the subcutaneous xenograft model, this regimen significantly suppresses tumor growth with no detectable systemic toxicity. Collectively, this work identifies BL-DVDMS-mediated PDT as a mechanistically defined, senescence-associated therapeutic strategy. This study provides a potential complementary treatment option for inoperable LC patients, particularly for managing residual disease and enhancing existing therapies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University",
    "Department of Urology, First Affiliated Hospital, Xi’an Jiaotong University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xing Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Minghai Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Yibo Mei"
    },
    {
      "affs": [
        1
      ],
      "name": "Pan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Rou Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuanquan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Dalin He"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7nveyr68yzrh2.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1935296",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1935296/full",
  "id": "7nveyr68yzrh2",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1935296/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2740|Photodynamic Therapy Research Studies"
    ]
  ],
  "openalex": "W7224087720",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7nveyr68yzrh2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1935296",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1935296/full"
    },
    {
      "first_seen": "2026-10-31T14:22:15Z",
      "native_id": "2cd6203758c34196a6306d42b14194cd",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fphar.2026.1935296"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RM1-950",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "BL-DVDMS-mediated photodynamic therapy induces oxidative response associated with cellular senescence via p53/GADD45A signaling in lung cancer",
  "title_text": "BL-DVDMS-mediated photodynamic therapy induces oxidative response associated with cellular senescence via p53/GADD45A signaling in lung cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:15Z",
  "url": "https://research.draconitic.com/paper/7nveyr68yzrh2",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}