{
  "abstract": "Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that poses a severe risk to maternal and fetal health. Owing to its incompletely elucidated pathogenesis, there is a lack of etiology-targeted therapeutic approaches in clinical practice, and pregnancy termination remains the primary intervention for PE. Emerging evidence indicates that histone post-translational modifications (HPTMs), a crucial class of epigenetic regulatory mechanisms, are extensively involved in the key pathological processes of PE by dynamically remodeling chromatin structures and regulating gene transcription. These processes include trophoblast dysfunction, placental vascular homeostasis dysregulation, immune-inflammatory disturbances, and endothelial dysfunction. In this review, we summarized the regulatory roles of HPTMs, such as methylation, acetylation, lactylation, citrullination, and ubiquitination, in PE pathogenesis. In addition, we discussed the potential and limitations of HPTMs and key modifying enzymes as candidate therapeutic targets and diagnostic biomarkers of PE. Overall, this review aims to summarize the reported roles of HPTMs in PE pathogenesis and examine promising diagnostic and therapeutic strategies from HPTMs perspective.",
  "abstract_shown": true,
  "affiliations": [
    "Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China",
    "Department of Medical Genetics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China",
    "Department of Laboratory, Peking University People’s Hospital Qingdao Hospital, Qingdao, Shandong, China",
    "Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuanxuan Ma"
    },
    {
      "affs": [
        2
      ],
      "name": "Renwei Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mengting Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jingli Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Bo Hou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shiguo Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7p25whjcp2t7t.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1973542",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13697007/",
  "id": "7p25whjcp2t7t",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://doi.org/10.3389/fendo.2026.1973542",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2729|Pregnancy and preeclampsia studies"
    ]
  ],
  "openalex": "W7221556586",
  "pdf_url": "https://europepmc.org/articles/PMC13697007?pdf=render",
  "pmcid": "PMC13697007",
  "pmid": "42935716",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7p25whjcp2t7t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:15Z",
      "native_id": "PMC13697007",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fendo.2026.1973542"
    },
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1973542",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1973542/full"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42935716",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935716"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Pregnancy and preeclampsia studies",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Role of histone post-translational modifications in preeclampsia: from pathogenesis to diagnostic and therapeutic strategies",
  "title_text": "Role of histone post-translational modifications in preeclampsia: from pathogenesis to diagnostic and therapeutic strategies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:14Z",
  "url": "https://research.draconitic.com/paper/7p25whjcp2t7t",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}