{
  "abstract": "Statin intolerance and side effects such as low-level myopathy limit statin use and the dose for optimal cholesterol lowering. We found that priming the NLRP3 inflammasome with bacterial components like lipopolysaccharide lowered the dose of statins that caused side effects in muscle cells. We then built models of low-level statin myopathy and found that muscle cell-autonomous statin-induced myopathy occurs through the NLRP3 inflammasome in vitro and in mice. Statin-induced muscle cell death and higher Atrogin-1 were prevented by blocking NLRP3 or restoring isoprenoids but not cholesterol. Statins reduced glycolysis in muscle cells, which required lower protein prenylation. Statins lowered YAP effector genes and promoted nuclear accumulation of FOXO. Activating YAP, restoring isoprenoids, or blocking NLRP3 mitigated nuclear FOXO accumulation, statin-induced muscle atrophy, and statinmediated lowering of protein synthesis. These results define a statin-induced myopathy pathway where metabolic danger engages the NLRP3 inflammasome and YAP via lower prenylation independent of cholesterol.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 25,
  "authors": [
    {
      "name": "Nazli Robin"
    },
    {
      "name": "Nicole Barra"
    },
    {
      "name": "Kevin Foley"
    },
    {
      "name": "Yujin Li"
    },
    {
      "name": "Akhilesh Tamrakar"
    },
    {
      "name": "Danish Patoli"
    },
    {
      "name": "Irena Rebalka"
    },
    {
      "name": "Tabitha Cree"
    },
    {
      "name": "Kaitlyn Bibby"
    },
    {
      "name": "Khang Nguyen"
    },
    {
      "name": "Rhianna Davis"
    },
    {
      "name": "Darryl Chan"
    },
    {
      "name": "Brittany Duggan"
    },
    {
      "name": "Brandyn Henriksbo"
    },
    {
      "name": "Megan Borges"
    },
    {
      "name": "Dana Kukje Zada"
    },
    {
      "name": "Han Fang"
    },
    {
      "name": "Daniel Marko"
    },
    {
      "name": "Paul Gregorevic"
    },
    {
      "name": "Kevin Watt"
    },
    {
      "name": "Richard Mills"
    },
    {
      "name": "Gary Sweeney"
    },
    {
      "name": "Thomas Hawke"
    },
    {
      "name": "Bénédicte Py"
    },
    {
      "name": "Jonathan Schertzer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7pcband6w5s08.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.adz3612",
  "fulltext_url": null,
  "id": "7pcband6w5s08",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://hal.science/hal-05772298v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W7165374832",
  "pdf_url": "https://hal.science/hal-05772298/document",
  "pmcid": null,
  "pmid": "42319925",
  "published": "2026-06-19",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/7pcband6w5s08.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:44Z",
      "native_id": "hal-05772298",
      "source": "hal",
      "url": "https://hal.science/hal-05772298v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP",
  "title_text": "Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:44Z",
  "url": "https://research.draconitic.com/paper/7pcband6w5s08",
  "venue": "Science Advances",
  "versions": []
}