{
  "abstract": "Carcinoma ex pleomorphic adenoma (CXPA) is a rare epithelial malignancy arising from benign pleomorphic adenoma. Cases with two distinct malignant components are exceedingly rare. Nonspecific clinical and imaging features and heterogeneous histology hinder differentiation from other salivary gland tumors, risking misdiagnosis and suboptimal therapy. We report two CXPA cases with dual malignant components and review the literature. Diagnosis relied on histopathology, immunohistochemistry, special stains, and fluorescence in situ hybridization (FISH); both cases showed two malignant components. Histopathology with IHC and FISH was essential, revealing morphological diversity and diagnostic complexity. Literature review confirms rarity and the inadequacy of preoperative clinical and radiological evaluation alone for distinction. Dual-malignant CXPA is a rare diagnostic challenge. Our observations may aid clinicians in reducing misdiagnosis and guiding management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Basic Medical Sciences of Oral Medicine, Affiliated Stomatological Hospital of Southwest Medical University",
    "Key Laboratory of Oral and Maxillofacial Prosthetic Reconstruction and Regeneration Luzhou City",
    "Institute of Stomatology, Southwest Medical University",
    "Department of Pathology, the Second Hospital of Hebei Medical University",
    "Department of Oral and Maxillofacial Surgery, the Second Hospital of Hebei Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qiuyue Mou"
    },
    {
      "affs": [
        3
      ],
      "name": "Dan Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dan Qin"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Kaiyu Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Minhai Nie"
    },
    {
      "affs": [
        4
      ],
      "name": "Yaoqiang Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xuqian Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7pht0dj6fhe33.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1981963",
  "fulltext_url": null,
  "id": "7pht0dj6fhe33",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1981963/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Salivary Gland Tumors Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223171321",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1981963/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7pht0dj6fhe33.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1981963",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1981963/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Salivary Gland Tumors Diagnosis and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Carcinoma ex pleomorphic adenoma containing two cancerous components: two case reports",
  "title_text": "Carcinoma ex pleomorphic adenoma containing two cancerous components: two case reports",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/7pht0dj6fhe33",
  "venue": "Frontiers in Oncology",
  "versions": []
}