{
  "abstract": "Background: Herein, we report a case of noninfectious intraocular inflammation (IOI) with hypopyon after an intravitreal aflibercept 8 mg injection for neovascular age-related macular degeneration.\n\nCase presentation: An 87-year-old Japanese man with neovascular age-related macular degeneration in the right eye was switched from intravitreal aflibercept 2 mg to aflibercept 8 mg to extend the treatment interval. Three days after the third aflibercept 8 mg injection, the patient presented with decreased vision without ocular pain. Slit-lamp examination revealed mild conjunctival injection and anterior chamber cells. Despite treatment with topical corticosteroids, the inflammation worsened the following day, with increased anterior chamber cells accompanied by a highly mobile hypopyon that shifted with head position. Smear microscopy of the aqueous humor showed neutrophils without detectable bacteria; the bacterial and fungal cultures were negative. Given the mild conjunctival injection, absence of ocular pain, and negative microbiological findings, noninfectious IOI was considered. The hypopyon rapidly resolved after a subconjunctival betamethasone injection on day 5. On day 8, vitritis and vitreous haze were observed and sub-Tenon triamcinolone acetonide was administered. By day 44, the best-corrected visual acuity had recovered to 20/20 and all inflammatory findings had completely resolved.\n\nConclusions: Noninfectious IOI with hypopyon may occur after an intravitreal aflibercept 8 mg injection. Even when hypopyon is present after an anti-vascular endothelial growth factor injection, noninfectious IOI should be included as a differential diagnosis in addition to infectious IOI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192 Japan"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroyuki Kamao",
      "orcid": "0000-0002-2194-7063"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryutaro Hiraki"
    },
    {
      "affs": [
        0
      ],
      "name": "Date Yuto"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsushi Miki"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuhei Kimura"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7pj0ngskhnkf9.bib",
  "cited_by": 0,
  "doi": "10.1186/s12886-026-05124-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13711720/",
  "id": "7pj0ngskhnkf9",
  "issns": [
    "1471-2415"
  ],
  "landing_url": "https://doi.org/10.1186/s12886-026-05124-w",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2731|Ocular Diseases and Behçet’s Syndrome"
    ]
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  "openalex": "W7171874022",
  "pdf_url": null,
  "pmcid": "PMC13711720",
  "pmid": "42934560",
  "published": "2026-07-30",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7pj0ngskhnkf9.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:27Z",
      "native_id": "PMC13711720",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12886-026-05124-w"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Ocular Diseases and Behçet’s Syndrome",
      "subfield": "general"
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  ],
  "title": "Noninfectious intraocular inflammation with hypopyon after intravitreal aflibercept 8 mg injection for neovascular age-related macular degeneration: a case report",
  "title_text": "Noninfectious intraocular inflammation with hypopyon after intravitreal aflibercept 8 mg injection for neovascular age-related macular degeneration: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:27Z",
  "url": "https://research.draconitic.com/paper/7pj0ngskhnkf9",
  "venue": "BMC Ophthalmology",
  "versions": []
}