{
  "abstract": "Clonal haematopoiesis (CH) arises from somatic mutations in haematopoietic stem cells that drive clonal expansion and increase haematological malignancy risk. Here we show that CH confers mutation- and dose-dependent risk of serious bacterial infection (SBI). Using a multi-parameter somatic variant calling and filtering approach, we identified 19,822 mutations across 43 CH genes in 40,560 of 590,537 individuals from three population cohorts (6.87%), validated in a combined analysis of 889,215 individuals. CH was associated with SBI development (HR = 1.22, P = 4.66 × 10⁻²⁹) and 28-day post-infection mortality (RR = 1.84, P = 0.0012), independent of malignancy and robust to adjustment for inflammatory comorbidities and ancestry. Recurrent mutations in SRSF2, DNMT3A, SF3B1, IDH2, and NRAS (n = 2143) conferred substantial absolute risks: 22–25% of individuals with expanded SRSF2 P95 clones developed SBI within 10 years. These associations were consistent across diverse populations and largely independent of bacterial strain.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Eleanor Fewings",
      "orcid": "0000-0001-9012-3220"
    },
    {
      "name": "Zhi Yu",
      "orcid": "0000-0003-4810-3474"
    },
    {
      "name": "Jacob C. Gutierrez"
    },
    {
      "name": "Buu Truong",
      "orcid": "0000-0003-0043-0812"
    },
    {
      "name": "Petko P. Fiziev"
    },
    {
      "name": "Jeremy McRae",
      "orcid": "0000-0003-3411-9248"
    },
    {
      "name": "Jeremy Schwartzentruber",
      "orcid": "0000-0002-6183-2092"
    },
    {
      "name": "Alexander G. Bick",
      "orcid": "0000-0001-5824-9595"
    },
    {
      "name": "Pradeep Natarajan",
      "orcid": "0000-0001-8402-7435"
    },
    {
      "name": "Caleb A. Lareau",
      "orcid": "0000-0003-4179-4807"
    },
    {
      "name": "Jacob C. Ulirsch"
    },
    {
      "name": "Kyle Kai-How Farh",
      "orcid": "0000-0001-6947-8537"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7pmwgkwd7x21z.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77934-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737001/",
  "id": "7pmwgkwd7x21z",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77934-x",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7220853201",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77934-x_reference.pdf",
  "pmcid": "PMC13737001",
  "pmid": "42982834",
  "published": "2026-10-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/7pmwgkwd7x21z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-77934-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77934-x"
    },
    {
      "first_seen": "2026-11-09T12:22:19Z",
      "native_id": "PMC13737001",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77934-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "Clonal haematopoiesis subtypes confer dose-dependent risk of serious bacterial infection",
  "title_text": "Clonal haematopoiesis subtypes confer dose-dependent risk of serious bacterial infection",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:19Z",
  "url": "https://research.draconitic.com/paper/7pmwgkwd7x21z",
  "venue": "Nature Communications",
  "versions": []
}