{ "abstract": "Background\n\nData from the ASSIST registry were analyzed to assess whether site-reported expanded Treatment in Cerebral Infarction (eTICI) scores differ from those reported by the core lab during off hours compared with normal hours. We also assessed whether outcomes are worse in procedures performed during off hours.Methods\n\nDetails from the registry have been previously published. Regression models were performed for first-pass treatment of target occlusion resulting in ≥2c by the core lab, agreement for final pass ≥2c, modified Rankin Scale 0 to 2 at 90 days, and whether first-pass eTICI ≥2c agreed between the core lab and site-reported assessments.Results\n\nA total of 1318 patients were included. Overall, agreement between core-lab and site-reported eTICI for first-pass eTICI ≥2c occurred in 86.7% and 78.5% for final eTICI ≥2c. Agreement for first-pass and final-pass eTICI ≥2c occurred in 87.2% and 77.7% during normal hours and 86.1% and 79.3% during off hours. Good functional outcomes occurred in 55.5% of patients presenting during normal hours and 53.8% of patients presenting during off hours. Off-hour versus normal-hour procedures were not significantly associated with first-pass efficacy, modified Rankin Scale 0 to 2 at 90 days, or whether first-pass eTICI agreed between the core lab and site-reported assessments in adjusted regression analyses.Conclusions\n\nThere was a higher level of agreement between core-lab and site-reported first-pass eTICI scores during all hours, while agreement occurred less often for final reperfusion. These results suggest a high level of correlation regardless of the time of the procedure between site-adjudicated and core-lab-adjudicated successful reperfusion grading. There were no significant differences in outcomes irrespective of the timing of thrombectomy.Registration\n\nURL: https://www.clinicaltrials.gov; Unique identifier: NCT03845491.", "abstract_shown": true, "affiliations": [ "Aurora Neurosciences Innovation Institute, Advocate Aurora Health, Milwaukee, WI (S.D.).", "Hospital Son Espases, Mallorca, Spain (S.M.).", "McLaren Regional Medical Center, Macomb, MI (B.N.).", "Medical University of South Carolina, Charleston (A.S.).", "Klinikum Vest Recklinghausen, Recklinghausen, Germany (C.L.).", "Hospital Clínico Universitario de Valladolid, Spain (M.M.-G.).", "Rhode Island Hospital, Providence (R.M.).", "Ghent University Hospital, Belgium (L.D.).", "Hospital Universitario Central de Asturias-HUCA, Oviedo, Spain (P.V.).", "Neuroscience Department, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH (O.O.Z.).", "Stryker Neurovascular, Fremont, CA (L.L.P.).", "Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles (D.S.L.).", "Uniklinik Heidelberg, Germany (M.M.).", "Department of Neurology, WellStar Health System, Marietta, GA (R.G.)." ], "article_type": "research article", "arxiv": null, "author_total": 14, "authors": [ { "affs": [ 0 ], "name": "Sudeepta Dandapat", "orcid": "0000-0003-3744-7845" }, { "affs": [ 1 ], "name": "Salvador Miralbés" }, { "affs": [ 2 ], "name": "Bharath Naravetla", "orcid": "0009-0005-0322-5824" }, { "affs": [ 3 ], "name": "Alejandro Spiotta" }, { "affs": [ 4 ], "name": "Christian Loehr", "orcid": "0000-0001-7572-9734" }, { "affs": [ 5 ], "name": "Mario Martínez-Galdámez", "orcid": "0000-0002-8024-4712" }, { "affs": [ 6 ], "name": "Ryan McTaggart", "orcid": "0000-0001-5853-5161" }, { "affs": [ 7 ], "name": "Luc Defreyne", "orcid": "0000-0001-5814-2798" }, { "affs": [ 8 ], "name": "Pedro Vega", "orcid": "0000-0002-7446-4540" }, { "affs": [ 9 ], "name": "Osama O Zaidat", "orcid": "0000-0003-4881-4698" }, { "affs": [ 10 ], "name": "Lori Lyn Price", "orcid": "0000-0003-0664-8978" }, { "affs": [ 11 ], "name": "David S Liebeskind", "orcid": "0000-0002-5109-8736" }, { "affs": [ 12 ], "name": "Markus Möhlenbruch", "orcid": "0000-0002-5075-704X" }, { "affs": [ 13 ], "name": "Rishi Gupta", "orcid": "0000-0003-1505-2498" } ], "bibtex": "https://research.draconitic.com/paper/7q8vmja0qs8za.bib", "cited_by": 0, "doi": "10.1161/svin.126.002502", "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727278/?tool=EBI", "id": "7q8vmja0qs8za", "issns": [ "2694-5746" ], "landing_url": "https://europepmc.org/article/PMC/PMC13727278", "language": "eng", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "10155" ], [ "heading", "10173" ], [ "heading", "10178" ], [ "heading", "Original Research" ], [ "openalex", "2713|Acute Ischemic Stroke Management" ] ], "openalex": "W7220857088", "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727278/pdf/?tool=EBI", "pmcid": "PMC13727278", "pmid": "42974600", "published": "2026-10-07", "publisher": "Wolters Kluwer Health", "ris": "https://research.draconitic.com/paper/7q8vmja0qs8za.ris", "sources": [ { "first_seen": "2026-11-03T15:20:51Z", "native_id": "PMC:PMC13727278", "source": "europepmc", "url": "https://europepmc.org/article/PMC/PMC13727278" }, { "first_seen": "2026-11-04T15:20:49Z", "native_id": "MED:42974600", "source": "europepmc", "url": "https://europepmc.org/article/MED/42974600" }, { "first_seen": "2026-11-05T12:23:23Z", "native_id": "PMC13727278", "source": "pmc", "url": "https://doi.org/10.1161/svin.126.002502" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2713|Acute Ischemic Stroke Management", "subfield": "epidemiology-public-health" } ], "title": "Site Versus Core Lab-Adjudicated First- and Final-Pass eTICI Scores Compared During Off and Normal Hours: Insights From the ASSIST Registry", "title_text": "Site Versus Core Lab-Adjudicated First- and Final-Pass eTICI Scores Compared During Off and Normal Hours: Insights From the ASSIST Registry", "type": "peer-reviewed", "updated_at": "2026-11-06T12:22:59Z", "url": "https://research.draconitic.com/paper/7q8vmja0qs8za", "venue": "Stroke (Hoboken, N.J.)", "versions": [] }