{
  "abstract": "Introduction: Liver transplantation involves significant Ischemia-Reperfusion Injury (IRI). Recipients frequently exhibit features of endothelial dysfunction, such as inflammation and coagulopathy, which may be associated with adverse outcomes, including early allograft dysfunction (EAD). Pentraxin-3 (PTX-3) is involved in vascular endothelial inflammation and dysfunction, and is synthesized by endothelial cells and leukocytes. In this retrospective cohort study, we hypothesized that PTX-3 levels are associated with EAD.\n\nMethods: PTX-3 levels were quantified in plasma samples collected during liver transplantation at the following time points: start of surgery (T1); end of liver dissection (T2); after reperfusion (T3 at 15 minutes; T4 60-120 minutes). Control samples from healthy living donors were collected at the start and end of surgery.\n\nResults: Plasma PTX-3 levels were higher during liver transplantation than in healthy controls at T1 (median 1.72 ng/mL, IQR 1.13-2.44 vs. 0.57 ng/mL, IQR 0.44-0.74), p<0.01, and increased over time in serial samples collected at T1, T3, and T4 (n = 50), p<0.001. In those who developed EAD, delta-PTX-3 after reperfusion (T3 to T4) was greater (median 12.3 ng/mL, IQR 6.65-18.7, n=17) compared to those without EAD (median 6.59 ng/mL, IQR 2.87-13.2, n=34), p=0.048, but there was no significant difference in final T4 PTX-3 levels. Delta-PTX-3 after reperfusion was greater in recipients of grafts that received normothermic machine perfusion (NMP) (median 12.7 ng/mL, IQR: 7.90-16.3, n=19), vs. Living Donor Liver Transplants (median 5.79ng/mL, IQR 2.60-10.2, n=24), p=0.02.\n\nDiscussion: Circulating PTX-3 levels increased during liver transplantation, with the highest levels after reperfusion. This suggests IRI triggered an increase in PTX-3. After reperfusion, delta-PTX-3, but not final PTX-3, was associated with an increased incidence of EAD and was greatest in recipients of grafts after NMP, suggesting NMP may involve earlier activation of pathways downstream of IRI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesia and Perioperative Care, University of California San Francisco , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alexandria Page"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael P. Bokoch"
    },
    {
      "affs": [
        0
      ],
      "name": "Dieter Adelmann"
    },
    {
      "affs": [
        0
      ],
      "name": "Rachel Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Judith Hellman"
    },
    {
      "affs": [
        0
      ],
      "name": "Kerstin Kolodzie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7rkevyg6m1q4z.bib",
  "cited_by": 0,
  "doi": "10.3389/frtra.2026.1920891",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719452/?tool=EBI",
  "id": "7rkevyg6m1q4z",
  "issns": [
    "2813-2440"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719452",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Organ Transplantation Techniques and Outcomes"
    ]
  ],
  "openalex": "W7222485229",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719452/pdf/?tool=EBI",
  "pmcid": "PMC13719452",
  "pmid": "42964131",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7rkevyg6m1q4z.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13719452",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719452"
    },
    {
      "first_seen": "2026-11-02T12:23:25Z",
      "native_id": "PMC13719452",
      "source": "pmc",
      "url": "https://doi.org/10.3389/frtra.2026.1920891"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Organ Transplantation Techniques and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Pentraxin-3 dynamics during liver transplantation and association with early allograft dysfunction",
  "title_text": "Pentraxin-3 dynamics during liver transplantation and association with early allograft dysfunction",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:30Z",
  "url": "https://research.draconitic.com/paper/7rkevyg6m1q4z",
  "venue": "Frontiers in transplantation",
  "versions": []
}