{
  "abstract": "Background/Objectives: Surveillance of intraductal papillary mucinous neoplasms (IPMNs) provides a clinically relevant window in which biological changes associated with pancreatic ductal adenocarcinoma (PDAC) development may potentially be investigated before advanced disease occurs. Nanoparticle-enabled protein corona (PC) fingerprinting has shown analytical potential in PDAC, but the extent to which different nanoplatforms recover distinct information across the biologically proximate IPMN-PDAC spectrum remains unclear. This exploratory study compared three nanoplatform configurations to identify a candidate workflow for subsequent validation. Methods: Plasma from 22 patients with de novo PDAC (n = 11), IPMN (n = 6), or IPMN-derived PDAC (n = 5) was incubated with graphene oxide (GO) nanosheets, gold nanoparticles (AuNPs), or cationic DOTAP-DOPE liposomes. Wash-resistant PCs were analyzed by SDS-PAGE, quantified across predefined molecular weight (MW) regions, and evaluated using exploratory linear discriminant analysis with repeated stratified cross-validation. Results: The three nanoplatforms generated non-equivalent electrophoretic PC architectures. In this small exploratory cohort, GO showed the broadest pattern of nominal clinical-group-associated variation in relative MW-region contributions and yielded internal cross-validation AUC estimates of 0.955 for IPMN versus de novo PDAC, 0.767 for IPMN versus IPMN-derived PDAC, and 0.927 for IPMN-derived versus de novo PDAC. Corresponding AUCs were 0.606–0.700 for AuNPs and 0.621–0.691 for liposomes. Conclusions: GO provided the broadest group-associated variation and numerically highest internal discrimination estimates, supporting its prioritization for independent validation and prospective longitudinal evaluation in IPMN surveillance.",
  "abstract_shown": true,
  "affiliations": [
    "Operative Research Unit of Laparoscopic and Minimally Invasive Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy",
    "Operative Research Unit of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy",
    "Research Unit of General Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sara Elsa Aita",
      "orcid": "0009-0005-9280-3293"
    },
    {
      "affs": [
        1
      ],
      "name": "Vincenzo La Vaccara"
    },
    {
      "affs": [
        1
      ],
      "name": "Roberto Cammarata"
    },
    {
      "affs": [
        0
      ],
      "name": "Marco Talarico"
    },
    {
      "affs": [
        1
      ],
      "name": "Federica Giordano",
      "orcid": "0009-0002-5756-2947"
    },
    {
      "affs": [
        1
      ],
      "name": "Roberto Coppola"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Damiano Caputo",
      "orcid": "0000-0001-7058-1945"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7rnnqfjhj3ty4.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203275",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702717/?tool=EBI",
  "id": "7rnnqfjhj3ty4",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3275",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7221533533",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702717/pdf/?tool=EBI",
  "pmcid": "PMC13702717",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7rnnqfjhj3ty4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203275",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3275"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13702717",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702717"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "Plasma Protein Corona Fingerprinting Across Intraductal Papillary Mucinous Neoplasms and Pancreatic Ductal Adenocarcinoma: A Comparative Proof-of-Concept Study",
  "title_text": "Plasma Protein Corona Fingerprinting Across Intraductal Papillary Mucinous Neoplasms and Pancreatic Ductal Adenocarcinoma: A Comparative Proof-of-Concept Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:34Z",
  "url": "https://research.draconitic.com/paper/7rnnqfjhj3ty4",
  "venue": "Cancers",
  "versions": []
}