{
  "abstract": "Gut microbiota (GM) alterations and related metabolic outputs have been implicated in metabolic syndrome (MetS) and early cardiometabolic risk. However, the associations between GM alterations and MetS, and their relationship with the marked interindividual variability in cardiovascular risk, remain incompletely defined. We conducted a cross-sectional study in individuals with obesity (n = 176) to evaluate associations between GM features and MetS clinical traits using 16S amplicon profiling data. Prevalence of individual MetS traits was 37.4% for hyperglycemia, 23.4% for hypertriglyceridemia, 54.0% for hypertension, and 52.1% for low HDL cholesterol, with 51.1% of participants meeting criteria for MetS overall. Comparative analysis of 16S rRNA amplicon sequencing data identified a shared gut microbial signature comprising 45 ASVs across MetS clinical components. Members of Prevotellaceae and Ruminococcaceae were consistently reduced in MetS, whereas Veillonella and Streptococcus were enriched. Reduced microbial alpha diversity was observed in individuals with MetS. PICRUSt2-based functional inference indicated lower representation of pathways related to complex carbohydrate utilization and short-chain fatty acid (SCFA) metabolism in MetS-positive individuals. Our results, derived from two independent datasets, indicate that MetS is associated with a depletion of bacterial taxa involved in complex carbohydrate metabolism and SCFA production.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy",
    "Center for Advanced Studies and Technology (CAST), ‘G. D’Annunzio’ University of Chieti-Pescara, 66013 Chieti, Italy",
    "Department of Innovative Technologies in Medicine and Dentistry, ‘G. D’Annunzio’ University of Chieti-Pescara, 66013 Chieti, Italy",
    "Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy",
    "Department for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166 Rome, Italy",
    "Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, Italy",
    "Unità di Endocrinologia, Diabetologia ed Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, 80131 Naples, Italy",
    "Università Cattolica del Sacro Cuore, 00168 Rome, Italy",
    "Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy",
    "Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine & Sciences, King’s College London, London WC2R 2LS, UK",
    "IRCCS NeuroMED, 86077 Pozzilli, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lorenzo Antonetti",
      "orcid": "0009-0002-3903-8113"
    },
    {
      "affs": [
        0
      ],
      "name": "Susanna Longo",
      "orcid": "0000-0002-7353-245X"
    },
    {
      "affs": [
        0
      ],
      "name": "Marina Cardellini"
    },
    {
      "affs": [
        0
      ],
      "name": "Viviana Casagrande"
    },
    {
      "affs": [
        0
      ],
      "name": "Rossella Menghini",
      "orcid": "0000-0001-8397-2355"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ilaria Cicalini",
      "orcid": "0000-0002-9792-2225"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Damiana Pieragostino",
      "orcid": "0000-0003-1015-3484"
    },
    {
      "affs": [
        3
      ],
      "name": "Eleonora Poggiogalle",
      "orcid": "0000-0003-0862-5892"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Francesco Frigerio",
      "orcid": "0000-0002-9502-3314"
    },
    {
      "affs": [
        3
      ],
      "name": "Claudia Piciocchi"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Vincenzo De Laurenzi"
    },
    {
      "affs": [
        6
      ],
      "name": "Silvia Savastano"
    },
    {
      "affs": [
        3
      ],
      "name": "Lorenzo Maria Donini",
      "orcid": "0000-0003-4692-4754"
    },
    {
      "affs": [
        7,
        8,
        9
      ],
      "name": "Geltrude Mingrone"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Massimo Federici"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7rvrk5tpe84nn.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219701",
  "fulltext_url": null,
  "id": "7rvrk5tpe84nn",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9701",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7rvrk5tpe84nn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:58Z",
      "native_id": "10.3390/ijms27219701",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9701"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Use of 16S rRNA Gut Microbiome Analysis to Identify Shared Microbial Signatures Across Metabolic Syndrome Components in Obese Subjects",
  "title_text": "Use of 16S rRNA Gut Microbiome Analysis to Identify Shared Microbial Signatures Across Metabolic Syndrome Components in Obese Subjects",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:54Z",
  "url": "https://research.draconitic.com/paper/7rvrk5tpe84nn",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}