{
  "abstract": "Background: Germline pathogenic variants in BRCA1 and BRCA2 are established contributors to hereditary breast cancer, yet their separate prognostic effects in non-metastatic disease remain uncertain because they are frequently analyzed as a single group. Methods: We retrospectively evaluated 360 patients with stage I-III invasive breast cancer who underwent germline genetic testing. Patients were categorized as BRCA-negative (n = 281), BRCA1-positive (n = 43), or BRCA2-positive (n = 36). Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier methods and Cox proportional hazards models with adjustment for molecular subtype and clinicopathological variables. Results: During follow-up, 76 DFS events and 27 deaths were observed. BRCA2 positivity was independently associated with worse DFS (hazard ratio [HR] 2.13, 95% confidence interval [CI] 1.14-3.98; p = 0.017), whereas BRCA1 positivity showed an association with improved OS (HR 0.08, 95% CI 0.01-0.51; p = 0.007). The OS finding should be interpreted cautiously because of the limited number of death events and the risk of model instability. Conclusions: Germline BRCA1 and BRCA2 variants may have divergent prognostic implications in non-metastatic breast cancer and should not be treated as a single homogeneous prognostic entity. Separate evaluation of these variants may improve risk stratification and support more individualized patient management, although validation in larger cohorts is warranted.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Medical Oncology, Department of Internal Medicine, Trakya University School of Medicine, 22130 Edirne, Turkey.",
    "Department of Radiation Oncology, Trakya University School of Medicine, 22130 Edirne, Turkey.",
    "Department of Biostatistics, Trakya University School of Medicine, 22130 Edirne, Turkey.",
    "Department of Medical Genetics, Trakya University School of Medicine, 22130 Edirne, Turkey.",
    "Trakya University School of Medicine, 22130 Edirne, Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ismail Bayrakci"
    },
    {
      "affs": [
        1
      ],
      "name": "Rusen Cosar",
      "orcid": "0000-0002-7953-8887"
    },
    {
      "affs": [
        2
      ],
      "name": "Necdet Sut"
    },
    {
      "affs": [
        3
      ],
      "name": "Hakan Gurkan",
      "orcid": "0000-0002-8967-6124"
    },
    {
      "affs": [
        4
      ],
      "name": "Omer Faruk Cetinkaya"
    },
    {
      "affs": [
        4
      ],
      "name": "Eylul Senodeyici"
    },
    {
      "affs": [
        0
      ],
      "name": "Didem Divriklioglu"
    },
    {
      "affs": [
        0
      ],
      "name": "Gizem Bakir Kahveci"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmet Kucukarda"
    },
    {
      "affs": [
        0
      ],
      "name": "Muhammet Bekir Hacioglu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bulent Erdogan",
      "orcid": "0000-0002-2158-3490"
    },
    {
      "affs": [
        0
      ],
      "name": "Sernaz Topaloglu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7rwqtrqw9bpbd.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18193073",
  "fulltext_url": "https://europepmc.org/articles/PMC13664164",
  "id": "7rwqtrqw9bpbd",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882768",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|BRCA gene mutations in cancer"
    ]
  ],
  "openalex": "W7213975536",
  "pdf_url": "https://europepmc.org/articles/PMC13664164?pdf=render",
  "pmcid": "PMC13664164",
  "pmid": "42882768",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7rwqtrqw9bpbd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42882768",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882768"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|BRCA gene mutations in cancer",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Divergent Prognostic Impact of Germline BRCA1 and BRCA2 Variants in Non-Metastatic Breast Cancer: A Real-World Cohort Study.",
  "title_text": "Divergent Prognostic Impact of Germline BRCA1 and BRCA2 Variants in Non-Metastatic Breast Cancer: A Real-World Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/7rwqtrqw9bpbd",
  "venue": "Cancers",
  "versions": []
}