{
  "abstract": "Alzheimer’s disease (AD) and benign prostatic hyperplasia (BPH) are two prevalent age-related disorders with significant global healthcare burdens. Traditionally viewed as distinct conditions, emerging evidence suggests that they may share common pathophysiological mechanisms, including chronic inflammation, endocrine dysregulation, metabolic dysfunction, cardiovascular impairment, and sleep disturbances. This review synthesizes current epidemiological, mechanistic, and therapeutic insights linking BPH and AD, with a focus on their overlapping risk factors and molecular pathways. Although most of the currently available evidence is observational and cannot establish causality, understanding these interactions could inform novel preventive and therapeutic strategies to mitigate the dual burden of neurodegenerative and urological conditions in older populations.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University",
    "Department of Clinical Medicine, Qingdao Medical College, Qingdao University",
    "Department of Urology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University",
    "School of Business and Management, Jilin University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Min Song"
    },
    {
      "affs": [
        1
      ],
      "name": "Anxu Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Hao Liang"
    },
    {
      "affs": [
        2
      ],
      "name": "Qingya Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Bing Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Jie Cui"
    },
    {
      "affs": [
        2
      ],
      "name": "Yue Qiu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7rz493n3v2ccv.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1817059",
  "fulltext_url": null,
  "id": "7rz493n3v2ccv",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1817059/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7rz493n3v2ccv.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T00:21:26Z",
      "native_id": "10.3389/fneur.2026.1817059",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1817059/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2295",
      "subfield": "neurology"
    }
  ],
  "title": "Shared mechanisms and therapeutic horizons: exploring the potential interplay between benign prostatic hyperplasia/lower urinary tract symptoms and Alzheimer’s disease",
  "title_text": "Shared mechanisms and therapeutic horizons: exploring the potential interplay between benign prostatic hyperplasia/lower urinary tract symptoms and Alzheimer’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T00:21:25Z",
  "url": "https://research.draconitic.com/paper/7rz493n3v2ccv",
  "venue": "Frontiers in Neurology",
  "versions": []
}