{
  "abstract": "Calibration of cardiovascular models is essential to their clinical utility. We provide a full description of the calibration of a non-linear, dynamic model using global optimisation methods. Specifically, we consider an experimental cohort response in a closed-loop, baro-regulated cardiovascular model, in the setting of induced central hypovolemia.We propose a framework for simplifying calibration of dynamic, regulated models. We perform global sensitivity analysis and orthogonality analysis of a 58-parameter non-linear cardiovascular model including the baroreflex, to select an optimal subset of parameters for model calibration. We fit the model to relative Lower Body Negative Pressure data, using global optimisation (Differential Evolution method), searching a reduced input parameter space. Global sensitivity analysis and orthogonality analysis revealed multiple higher-order interactions within the model, as well as areas of similar influence of input parameters, on the components of the objective function. The model was fitted using only baroreflex parameters. Relative errors in the estimation of heart rate, mean arterial pressure, and stroke volume were reduced from −15.03%, 1.60% and 42.06% before calibration to 0.42%, −1.37% and 0.61% after the fitting, respectively.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom",
    "Sano Centre for Computational Medicine, Kraków, Poland",
    "Astellas Pharma Europe Ltd, Addlestone, England",
    "Insigneo Institute for Healthcare Technology, Sheffield, United Kingdom",
    "School of Computer Science, University of Sheffield, Sheffield, United Kingdom",
    "NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom",
    "Department of Anesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway",
    "Department of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo, Norway",
    "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway",
    "Faculty of Computer Science, AGH University of Kraków, Kraków, Poland"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Karolina Tlałka"
    },
    {
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        1
      ],
      "name": "Harry Saxton"
    },
    {
      "affs": [
        2
      ],
      "name": "Ian Halliday"
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    {
      "affs": [
        3
      ],
      "name": "Xu Xu"
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    {
      "affs": [
        4
      ],
      "name": "Andrew Narracott"
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    {
      "affs": [
        5
      ],
      "name": "Daniel James Taylor"
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    {
      "affs": [
        6
      ],
      "name": "Lars Øivind Høiseth"
    },
    {
      "affs": [
        7
      ],
      "name": "Jonny Hisdal"
    },
    {
      "affs": [
        8
      ],
      "name": "David Rodney Hose"
    },
    {
      "affs": [
        9
      ],
      "name": "Maciej Malawski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7s8c2f1ff9e2g.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0362073",
  "fulltext_url": null,
  "id": "7s8c2f1ff9e2g",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0362073",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Heart Rate Variability and Autonomic Control"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Arteries/Pulmonary arteries"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Heart"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Physiological parameters"
    ],
    [
      "plos",
      "/Computer and information sciences/Systems science/Nonlinear dynamics"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Arteries/Pulmonary arteries"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Heart"
    ],
    [
      "plos",
      "/Medicine and health sciences/Cardiology/Heart rate"
    ],
    [
      "plos",
      "/Medicine and health sciences/Vascular medicine/Blood pressure"
    ],
    [
      "plos",
      "/Physical sciences/Mathematics/Applied mathematics/Algorithms/Evolutionary algorithms"
    ],
    [
      "plos",
      "/Physical sciences/Mathematics/Optimization"
    ],
    [
      "plos",
      "/Physical sciences/Mathematics/Systems science/Nonlinear dynamics"
    ],
    [
      "plos",
      "/Research and analysis methods/Computational techniques/Evolutionary computation/Evolutionary algorithms"
    ],
    [
      "plos",
      "/Research and analysis methods/Simulation and modeling/Algorithms/Evolutionary algorithms"
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  "openalex": "W7225417608",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/7s8c2f1ff9e2g.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:24Z",
      "native_id": "10.1371/journal.pone.0362073",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0362073"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Calibration of a fully closed-loop lumped-parameter cardiovascular model with baroreflex in response to induced central hypovolemia",
  "title_text": "Calibration of a fully closed-loop lumped-parameter cardiovascular model with baroreflex in response to induced central hypovolemia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:48Z",
  "url": "https://research.draconitic.com/paper/7s8c2f1ff9e2g",
  "venue": "PLOS One",
  "versions": []
}