{
  "abstract": "Cell proliferation is a fundamental driver of disease aggressiveness in multiple myeloma (MM); however, transcriptional programs underpinning proliferative capacity remain incompletely defined. Using Affymetrix microarray data from 136 Mayo Clinic patients with MM with paired plasma cell labeling index (PCLI), we performed a differential expression analysis to identify genes consistently associated with proliferative activity. These genes were subsequently incorporated into the development of a prognostic model using baseline RNA sequencing (RNA-seq) profiles in purified CD138⁺ cells from 656 patients in the CoMMpass cohort, in which an elastic net-based Cox model yielded an 8-gene-based proliferation score (GPS). Differential expression analysis identified 108 proliferation-associated genes, and the resulting 8-gene GPS (CHEK1, EXO1, MCM4, TK1, KIF14, SEPTIN11, PHF19, and HMGB3) formed a highly connected biological network enriched for DNA damage response and cell cycle regulation. CHEK1, TK1, EXO1, and MCM4 were mapped in a large network with CHEK1 as the hub gene. In the CoMMpass data set, on dividing the GPS score by the median, the high-GPS group (n = 328) had a median overall survival (OS) of 63.6 months (95% confidence interval, 56.5-76.7), whereas the low-GPS group (n = 328) had a median OS of 106.1 months (P < .001). Similarly, in another Mayo Clinic RNA-seq cohort, high-GPS group (n = 12) demonstrated worse survival (median OS, 39.2 vs 157.1 months for the low-GPS group; P = .03). GPS emerged as an independent prognostic factor alongside high-risk markers and also predicted S-phase content in an independent data set.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Hematology, Mayo Clinic, Rochester, MN",
    "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN",
    "Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ",
    "Division of Hematopathology, Mayo Clinic, Rochester, MN"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arwa Bohra"
    },
    {
      "affs": [
        1
      ],
      "name": "Surendra Dasari"
    },
    {
      "affs": [
        0
      ],
      "name": "Wilson I. Gonsalves"
    },
    {
      "affs": [
        0
      ],
      "name": "Richard K. Kandasamy"
    },
    {
      "affs": [
        0
      ],
      "name": "Prashant Kapoor"
    },
    {
      "affs": [
        0
      ],
      "name": "Saurabh Zanwar"
    },
    {
      "affs": [
        0
      ],
      "name": "Moritz Binder"
    },
    {
      "affs": [
        2
      ],
      "name": "Esteban Braggio"
    },
    {
      "affs": [
        1
      ],
      "name": "Erik Jessen"
    },
    {
      "affs": [
        0
      ],
      "name": "Angela Dispenzieri"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael M. Timm"
    },
    {
      "affs": [
        3
      ],
      "name": "Dragan Jevremovic"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Vincent Rajkumar"
    },
    {
      "affs": [
        0
      ],
      "name": "Shaji Kumar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7s92rzdpecadt.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bneo.2026.100288",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717733/?tool=EBI",
  "id": "7s92rzdpecadt",
  "issns": [
    "2950-3280"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717733",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Lymphoid Neoplasia"
    ],
    [
      "openalex",
      "2720|Multiple Myeloma Research and Treatments"
    ]
  ],
  "openalex": "W7204095041",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717733/pdf/?tool=EBI",
  "pmcid": "PMC13717733",
  "pmid": "42959892",
  "published": "2026-08-24",
  "publisher": "The American Society of Hematology",
  "ris": "https://research.draconitic.com/paper/7s92rzdpecadt.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:39Z",
      "native_id": "PMC:PMC13717733",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717733"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959892",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959892"
    },
    {
      "first_seen": "2026-11-02T12:22:00Z",
      "native_id": "PMC13717733",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bneo.2026.100288"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Multiple Myeloma Research and Treatments",
      "subfield": "general"
    }
  ],
  "title": "A proliferation score defined by PCLI-anchored transcriptomics predicts outcomes in multiple myeloma",
  "title_text": "A proliferation score defined by PCLI-anchored transcriptomics predicts outcomes in multiple myeloma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:00Z",
  "url": "https://research.draconitic.com/paper/7s92rzdpecadt",
  "venue": "Blood neoplasia",
  "versions": []
}