{
  "abstract": "Recent studies indicate that injury-induced dedifferentiation generates transient regenerative progenitors (TRPs), which support tissue repair across multiple organs, including the liver. In vivo partial reprogramming using Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc; OSKM) produces intestinal TRPs closely resembling those arising from injury-induced dedifferentiation, but transgenic or viral approaches raise safety concerns because of prolonged expression. Here, we show that transient OSKM induction generates two distinct liver progenitor-like cell (LPLC) populations without injury and with limited activation of injury-associated immune responses. Single-nucleus RNA sequencing shows that one population resembles injury-induced LPLCs observed in acetaminophen-injured mouse and human livers. To develop a temporally controlled regenerative strategy, we establish a liver-targeted lipid nanoparticle system for OSKM mRNA delivery. OSKM mRNA-LNP treatment induces hepatocyte dedifferentiation and Sox9+ LPLC-like cell formation and is associated with enhanced regeneration after acetaminophen-induced injury. Together, these findings identify transient hepatic reprogramming as a strategy for inducing regenerative plasticity and support liver-targeted OSKM mRNA delivery as a potential approach for acute liver injury.",
  "abstract_shown": true,
  "affiliations": [
    "College of Pharmacy, Seoul National University, Seoul, Republic of Korea",
    "Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea",
    "Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea",
    "Brain Korea 21 (BK21) FOUR Program, Yonsei Education & Research Center for Biosystems, Yonsei University, Seoul, Republic of Korea",
    "College of Pharmacy, Sookmyung Women’s University, Seoul, Republic of Korea",
    "Cellartgen, Seoul, Republic of Korea",
    "Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea",
    "Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Beom-Ki Jo"
    },
    {
      "affs": [
        1
      ],
      "name": "Young Seok Song"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Woohyun Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Hee-Ji Eom"
    },
    {
      "affs": [
        1
      ],
      "name": "Yon Jae Lee"
    },
    {
      "affs": [
        4
      ],
      "name": "Jumee Kim"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Seunghee Hong"
    },
    {
      "affs": [
        1,
        5,
        6
      ],
      "name": "Seung-Woo Cho"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Hyuk-Jin Cha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7s9c99bdnst4s.bib",
  "cited_by": 1,
  "doi": "10.1016/j.xcrm.2026.103084",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710699/",
  "id": "7s9c99bdnst4s",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103084",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2721|Liver physiology and pathology"
    ]
  ],
  "openalex": "W7215092577",
  "pdf_url": null,
  "pmcid": "PMC13710699",
  "pmid": "42822446",
  "published": "2026-10-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7s9c99bdnst4s.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC13710699",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103084"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver physiology and pathology",
      "subfield": "general"
    }
  ],
  "title": "Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming",
  "title_text": "Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:37Z",
  "url": "https://research.draconitic.com/paper/7s9c99bdnst4s",
  "venue": "Cell Reports Medicine",
  "versions": []
}