{
  "abstract": "Metabolic reprogramming of tumor cells interacts with functional alterations of immune cells to establish an immunosuppressive tumor microenvironment, which constrains the efficacy of immunotherapy. Nanomedicine provides technical approaches for targeted delivery and controlled release of metabolic modulators. This review outlines major nanocarriers and their design principles, dissects the crosstalk among glucose, amino acid and lipid metabolism, and illustrates how nutrient competition and metabolic byproducts shape antitumor immune responses. It focuses on summarizing advances in nanodelivery strategies targeting these metabolic pathways and their combinatorial application with immunotherapy. Nanomedicine-mediated metabolic intervention holds promise for remodeling the tumor immune microenvironment. However, tumor cells and effector T cells share partial metabolic requirements, and nonselective inhibition may impair antitumor immunity. Improving the cell selectivity of interventions and validating long-term safety and clinical benefits represent key considerations for future translational research.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.",
    "Department of Gynecology, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hongpeng Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Fengyi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Zhang",
      "orcid": "0000-0002-9938-8433"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7savnsfszrh4n.bib",
  "cited_by": 0,
  "doi": "10.2147/ijn.s650413",
  "fulltext_url": "https://europepmc.org/articles/PMC13715856",
  "id": "7savnsfszrh4n",
  "issns": [
    "1176-9114",
    "1178-2013"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953814",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7223445204",
  "pdf_url": "https://europepmc.org/articles/PMC13715856?pdf=render",
  "pmcid": "PMC13715856",
  "pmid": "42953814",
  "published": "2026-10-24",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/7savnsfszrh4n.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42953814",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953814"
    },
    {
      "first_seen": "2026-11-01T12:23:03Z",
      "native_id": "PMC13715856",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ijn.s650413"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "A Narrative Review of Nanomedicine in Cancer Therapy: Modulating Metabolic Reprogramming to Enhance Immunotherapy.",
  "title_text": "A Narrative Review of Nanomedicine in Cancer Therapy: Modulating Metabolic Reprogramming to Enhance Immunotherapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:03Z",
  "url": "https://research.draconitic.com/paper/7savnsfszrh4n",
  "venue": "International journal of nanomedicine",
  "versions": []
}