{
  "abstract": "The tumor suppressor p53 and the transcription factors estrogen receptor and androgen receptor regulate growth in a sex-dependent hormone-responsive manner, as in breast and prostate tumors and muscle tissue. Using a model of transcriptional regulation, we investigated co-regulation between p53 and hormone receptors in different cellular contexts and highlight an enrichment in mammary and muscle cell types. Sequence, structural and epigenomic evidence demonstrate a broadly distributed functional 73-bp p53-estrogen receptor grammar spanning nucleosome entry/exit to dyad, while p53-androgen receptor grammar spans 146 bp. At a functional breast cancer enhancer regulating Cyclin D, varied spacing led to lower predicted p53 binding. Genome-wide analysis found a major role of Alu sequences in distributing this grammar, in particular in mTORC1 pathway genes, with an evolutionary association of primate body-size sexual dimorphism and muscle aging.",
  "abstract_shown": true,
  "affiliations": [
    "Columbia University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "X. Fu"
    },
    {
      "name": "Q. Cai"
    },
    {
      "name": "P. Satya"
    },
    {
      "name": "R. Rabadan"
    },
    {
      "name": "A. J. Levine"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7sc792jez4kmc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.26.754600",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754600v1.full",
  "id": "7sc792jez4kmc",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754600v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7214657968",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754600v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7sc792jez4kmc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:52Z",
      "native_id": "10.64898/2026.09.26.754600",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754600v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Nucleosome-scale p53-hormone receptor grammar distributed by Alu elements",
  "title_text": "Nucleosome-scale p53-hormone receptor grammar distributed by Alu elements",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:52Z",
  "url": "https://research.draconitic.com/paper/7sc792jez4kmc",
  "venue": "bioRxiv",
  "versions": []
}