{
  "abstract": "Background: The incidence of p16-positive oropharyngeal squamous cell carcinoma (OPSCC) is increasing, with improved prognosis compared to non-HPV-related cancers. Standard treatment of locally advanced OPSCC involves high-dose cisplatin (HDC) with radiation but is associated with significant toxicity. Low-dose cisplatin (LDC) administered weekly has shown comparable efficacy to HDC in prior studies. This study evaluates the real-world outcomes of LDC in p16-positive OPSCC in a regional centre. Material and methods: Patients treated with curative radiation and concurrent LDC (40 mg/m2 weekly) for p16-positive OPSCC from January 2015 to December 2021 were retrospectively analysed (n = 103). Primary endpoints included overall survival (OS) and progression-free survival (PFS), with secondary endpoints being loco-regional and distant recurrence rates, and chemotherapy-related toxicity. Results: Overall survival rates were 94%, 89%, and 84% at two, three, and five years, respectively. The progression-free survival rates were 90%, 83%, and 80% over the same periods. The low-risk group showed excellent outcomes with no loco-regional recurrences and low distant relapse rates (6% at 5 years). The intermediate-risk group had higher loco-regional recurrences (10% at 5 years) and a similar distant relapse rate (7% at 5 years). T4 or N3 disease patients had lower survival and higher distant relapse rates but excellent loco-regional control. The median cumulative cisplatin dose was 240 mg/m2, with no survival difference between those receiving ≥200 mg/m2 versus less. Toxicity led to dose reductions (8%), delays (13%), and early cessations (30%). Conclusions: LDC is effective for p16-positive OPSCC with manageable toxicity, showing outcomes comparable to outcomes previously reported in studies using HDC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Townsville University Hospital, Townsville, QLD 4814, Australia",
    "School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4222, Australia",
    "Department of Medical Oncology, Townsville University Hospital, Townsville, QLD 4814, Australia",
    "College of Medicine and Dentistry, James Cook University, Townsville, QLD 4814, Australia",
    "Department of Otolaryngology Head and Neck Surgery, Townsville University Hospital, Townsville, QLD 4814, Australia",
    "Department of Nutrition and Dietetics, Townsville University Hospital, Townsville, QLD 4814, Australia",
    "Department of Speech Pathology, Townsville University Hospital, Townsville, QLD 4814, Australia",
    "Australian Tropical Institute of Health and Medicine, James Cook University, Townsville, QLD 4814, Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nitin Niranjan"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Zulfiquer Otty"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Abhishek Joshi"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Marcus Hu"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Oskar Edkins"
    },
    {
      "affs": [
        5
      ],
      "name": "Sarah Deacon"
    },
    {
      "affs": [
        6
      ],
      "name": "Courtney Fisher"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Amy Brown"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Corinne Ryan"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Nathan Bain",
      "orcid": "0000-0002-3320-8444"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Joanne Tan"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Timothy Squire",
      "orcid": "0000-0002-7971-0069"
    },
    {
      "affs": [
        4
      ],
      "name": "Simon Liebenberg"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Sabe Sabesan"
    },
    {
      "affs": [
        0,
        3,
        7
      ],
      "name": "Daniel Tao Xing",
      "orcid": "0000-0001-5064-3408"
    },
    {
      "affs": [
        2
      ],
      "name": "Shivanshan Pathmanathan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7schckqvkxpjz.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203308",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702542/?tool=EBI",
  "id": "7schckqvkxpjz",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3308",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7221813692",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702542/pdf/?tool=EBI",
  "pmcid": "PMC13702542",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7schckqvkxpjz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203308",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3308"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13702542",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702542"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Retrospective Analysis of Efficacy and Toxicity of Low-Dose Weekly Cisplatin Concurrently with Radiotherapy for p16-Positive Oropharyngeal Squamous Cell Carcinoma",
  "title_text": "Retrospective Analysis of Efficacy and Toxicity of Low-Dose Weekly Cisplatin Concurrently with Radiotherapy for p16-Positive Oropharyngeal Squamous Cell Carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:34Z",
  "url": "https://research.draconitic.com/paper/7schckqvkxpjz",
  "venue": "Cancers",
  "versions": []
}