{
  "abstract": "Background: Patients aged 80 years or older with acute ischemic stroke (AIS) have heterogeneous functional-survival outcomes despite similar clinical severity. We evaluated whether a routine laboratory-derived Prognostic Inflammation-Nutrition Reserve Index (PINRI) was associated with the 180-day ordinal functional survival state.\n\nMethods: This single-center cohort study screened consecutive patients admitted with suspected AIS from January 2021 through December 2024. Admission PINRI combined an internally standardized logarithmic C-reactive protein-to-albumin ratio, the logarithmic systemic inflammatory response index, and the inverse of the prognostic nutritional index; no transportable clinical threshold was proposed. The primary outcome was 180-day modified Rankin Scale (mRS) 0–2, mRS 3–5, or death.\n\nResults: Among 278 analyzable patients, 111 (39.9%) achieved mRS 0–2, 114 (41.0%) had mRS 3–5, and 53 (19.1%) died; 167 (60.1%) experienced dependency or death. Each 1-SD increase in admission PINRI was associated with a worse functional survival state after adjusting for selected clinical covariates (adjusted common odds ratio [aOR], 1.98; 95% CI, 1.48–2.65; p < 0.001). The aOR for the highest versus lowest tertile was 3.43 (95% CI, 1.74–6.74; p < 0.001). The first-week PINRI burden remained associated with a worse outcome among 241 day-7 landmark survivors (aOR, 1.80; 95% CI, 1.19–2.72; p = 0.005). Adding PINRI improved the internally optimism-corrected C-statistic for dependency/death from 0.810 to 0.834 (difference, 0.024; p = 0.033). Comparator single-marker C-statistics were 0.821–0.825; none differed significantly from PINRI after false discovery rate (FDR) control.\n\nConclusion: Higher admission PINRI and first-week PINRI burden were associated with a worse 180-day functional survival state and provided modest incremental information beyond the clinical model. Multicenter validation and local calibration are required before implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Jiujiang First People's Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lianhong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinghua Peng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7sd2dgx68wcfj.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1910335",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1910335/full",
  "id": "7sd2dgx68wcfj",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1910335/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC346-429"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
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  "openalex": "W7223289653",
  "pdf_url": "https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1910335/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7sd2dgx68wcfj.ris",
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      "native_id": "10.3389/fneur.2026.1910335",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1910335/full"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "A prognostic inflammation-nutrition reserve index for 180-day functional-survival outcomes after acute ischemic stroke in patients aged 80 years or older",
  "title_text": "A prognostic inflammation-nutrition reserve index for 180-day functional-survival outcomes after acute ischemic stroke in patients aged 80 years or older",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:11Z",
  "url": "https://research.draconitic.com/paper/7sd2dgx68wcfj",
  "venue": "Frontiers in Neurology",
  "versions": []
}