{
  "abstract": "Background/Objectives: Quantitative patent ductus arteriosus (PDA) geometry in congenital heart disease (CHD), particularly in relation to aortic arch abnormalities, is incompletely characterized. We evaluated CT-derived PDA geometry. Methods: This retrospective exploratory single-center study included 168 infants with CHD and a PDA on cardiovascular CT. Aortic-end, pulmonary-end, and mid-duct diameters and ductal length were measured. The Ductal Length-to-Diameter Index (LDI), selected during exploratory analysis, was defined as ductal length divided by the mean end diameter. Seventy-three patients had CT-documented aortic arch obstruction or hypoplasia. Results: LDI was lower in patients with arch obstruction/hypoplasia than in those without these findings (2.04 [1.39–2.84] vs. 3.51 [2.23–4.89]; p < 0.001; rank-biserial r = −0.473) and remained associated after adjustment for age, weight, and sex (OR per +1 LDI, 0.534; 95% CI, 0.412–0.693; p < 0.001). The association remained robust with a conservative definition restricted to coarctation or interrupted aortic arch. LDI had an interobserver ICC of 0.843 (95% CI, 0.685–0.954), with wide limits of agreement (−1.98 to +2.45). Conclusions: CT-documented aortic arch obstruction or hypoplasia is associated with lower LDI. This exploratory geometric association warrants prospective external validation before clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania",
    "Radiology and Medical Imaging Laboratory, Mureș County Emergency Clinical Hospital, 540136 Târgu Mureș, Romania",
    "Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540139 Târgu Mureș, Romania",
    "Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania",
    "Department of Surgery IV, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania",
    "Clinic of Cardiovascular Surgery, Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540139 Târgu Mureș, Romania"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Marian Pop",
      "orcid": "0000-0001-5324-9780"
    },
    {
      "affs": [
        0
      ],
      "name": "Liel Bargutin"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Răzvan-Andrei Licu",
      "orcid": "0009-0007-5406-1449"
    },
    {
      "affs": [
        1
      ],
      "name": "Marian Rotariu"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Diana-Ramona Iurian"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Tania Negovan"
    },
    {
      "affs": [
        2,
        4,
        5
      ],
      "name": "Horațiu Suciu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7stv7b5vmsjdv.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208017",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706272/?tool=EBI",
  "id": "7stv7b5vmsjdv",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8017",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Cardiovascular Conditions and Treatments"
    ]
  ],
  "openalex": "W7222661145",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706272/pdf/?tool=EBI",
  "pmcid": "PMC13706272",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7stv7b5vmsjdv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15208017",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8017"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13706272",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706272"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Cardiovascular Conditions and Treatments",
      "subfield": "imaging"
    }
  ],
  "title": "Quantitative CT Geometry of the Patent Ductus Arteriosus in Infants with Congenital Heart Disease: Association with Aortic Arch Obstruction or Hypoplasia",
  "title_text": "Quantitative CT Geometry of the Patent Ductus Arteriosus in Infants with Congenital Heart Disease: Association with Aortic Arch Obstruction or Hypoplasia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/7stv7b5vmsjdv",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}