{
  "abstract": "Occasionally, sarcoidosis can progress to fibrotic lung disease. Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrotic pattern characterized by upper lobe-predominant pleural and subpleural fibroelastoses. However, pathologically confirmed cases of PPFE in sarcoidosis patients have not been reported. We herein describe the case of a 59-year-old woman with long-standing pulmonary sarcoidosis who developed progressive upper lobe-predominant fibrosis and cystic changes, culminating in living-donor lung transplantation. Histopathological examination of the explanted lungs revealed pleural thickening and subpleural intra-alveolar fibroelastosis, consistent with PPFE in the absence of typical granulomatous lesions of sarcoidosis. This case provides the first pathological evidence that PPFE represents a fibrotic manifestation of end-stage pulmonary sarcoidosis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Masato Kono"
    },
    {
      "name": "Takahiko Saito"
    },
    {
      "name": "Takuma Sugiura"
    },
    {
      "name": "Misato Higasa"
    },
    {
      "name": "Fumiya Nihashi"
    },
    {
      "name": "Yuya Aono"
    },
    {
      "name": "Mineo Katsumata"
    },
    {
      "name": "Hideki Miwa"
    },
    {
      "name": "Yoshihiro Miki"
    },
    {
      "name": "Dai Hashimoto"
    },
    {
      "name": "Satona Tanaka"
    },
    {
      "name": "Hiroshi Date"
    },
    {
      "name": "Takafumi Suda"
    },
    {
      "name": "Hidenori Nakamura"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7t1gcskafcxqr.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.6496-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6496-25/_article",
  "id": "7t1gcskafcxqr",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6496-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2737|Sarcoidosis and Beryllium Toxicity Research"
    ]
  ],
  "openalex": "W7126377323",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6496-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7t1gcskafcxqr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.6496-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6496-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Sarcoidosis and Beryllium Toxicity Research",
      "subfield": "physiology"
    }
  ],
  "title": "Pleuroparenchymal Fibroelastosis Lesion in Explanted Lungs of a Patient with Fibrotic Pulmonary Sarcoidosis",
  "title_text": "Pleuroparenchymal Fibroelastosis Lesion in Explanted Lungs of a Patient with Fibrotic Pulmonary Sarcoidosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/7t1gcskafcxqr",
  "venue": "Internal Medicine",
  "versions": []
}