{
  "abstract": "The pathophysiology of depression involves multiple biological processes, including circuit dysfunction and impaired neuroplasticity, yet an integrative view linking these processes remains elusive. Here, we identify a convergent circuit for antidepressant response and plasticity modulation. We demonstrate that chemogenetic activation of the infralimbic cortex (IL) exerts rapid antidepressant-like effects across multiple behavioral domains in a mouse model of stress-induced depression. IL stimulation exerts top-down control over the hippocampus, enhancing structural plasticity, restoring long-term potentiation deficits and improving state-dependent network dynamics in the ventral hippocampus (vHIPP). We identify the thalamic nucleus reuniens (RE) as a necessary mediator of these effects. Notably, direct inhibition of RE, its inputs from IL or projections to vHIPP, blocks both IL stimulation-induced antidepressant response and the therapeutic and neuroplastic effects of ketamine. Our findings demonstrate that the functional IL → RE→vHIPP circuit plays a central role in the antidepressant response, linking circuit activity, hippocampal plasticity, and depressive-like behaviors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "name": "Maxime Veleanu"
    },
    {
      "name": "Louise Schuberth"
    },
    {
      "name": "Antje Kilias"
    },
    {
      "name": "Jakob Weber"
    },
    {
      "name": "Jan Warneke"
    },
    {
      "name": "Lovis Würz"
    },
    {
      "name": "Tim Schwär"
    },
    {
      "name": "Rebecca Heck"
    },
    {
      "name": "Joelle Müller"
    },
    {
      "name": "David H Sarrazin"
    },
    {
      "name": "Marguerite Anselin"
    },
    {
      "name": "Lukas Rutke"
    },
    {
      "name": "Guillermo Suarez Marchi"
    },
    {
      "name": "Stella Zimmermann"
    },
    {
      "name": "Zoe Borgeest"
    },
    {
      "name": "Martin Balzinger"
    },
    {
      "name": "Alina Blendinger"
    },
    {
      "name": "Anna Catarata"
    },
    {
      "name": "Samira Assaad Dib"
    },
    {
      "name": "Yaroslav Sych"
    },
    {
      "name": "Thibault Cholvin"
    },
    {
      "name": "Marlene Bartos"
    },
    {
      "name": "Katharina Domschke"
    },
    {
      "name": "Claus Normann"
    },
    {
      "name": "Stefan Vestring"
    },
    {
      "name": "Tsvetan Serchov"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7t2avfymjmkkw.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77248-y",
  "fulltext_url": null,
  "id": "7t2avfymjmkkw",
  "issns": [
    "2041-1723",
    "2041-1723"
  ],
  "landing_url": "https://hal.science/hal-05774532v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "1.sdv.sp"
    ],
    [
      "hal",
      "2.sdv.mhep.psm"
    ],
    [
      "hal",
      "2.sdv.neu.nb"
    ],
    [
      "hal",
      "2.sdv.sp.pharma"
    ],
    [
      "openalex",
      "2736|Treatment of Major Depression"
    ]
  ],
  "openalex": "W7204912409",
  "pdf_url": "https://hal.science/hal-05774532/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/7t2avfymjmkkw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:46Z",
      "native_id": "hal-05774532",
      "source": "hal",
      "url": "https://hal.science/hal-05774532v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.sp",
      "subfield": "pharmacology-toxicology"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.psm",
      "subfield": "psychiatry"
    }
  ],
  "title": "The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response",
  "title_text": "The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:46Z",
  "url": "https://research.draconitic.com/paper/7t2avfymjmkkw",
  "venue": "Nature Communications",
  "versions": []
}