{
  "abstract": "According to an epidemiological survey, myocardial infarction, ischemia-reperfusion injury, and aortic rupture usually occur in the morning and summer and are characterized by more severe symptoms and poorer prognosis. The occurrence, development, treatment difficulties, and poor prognosis of ischemic heart disease are closely related to circadian rhythm disorders and the abnormal transcription of circadian clock genes. Normal circadian rhythms regulate neurohumoral regulation and energy metabolism, thereby playing a protective or modulatory role in ischemic heart disease (IHD). HIF1α links the IHD and circadian signaling pathways through the hypoxia response element (HRE) and Per-Arnt-Sim (PAS) domains in gene promoters and enhancers.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, The Second Hospital of Jilin University, Changchun, 130021, P. R. China.",
    "Department of Hand Surgery, The First Hospital of Jilin University, Changchun, 130021, P. R. China.",
    "Department of Cardiology, The Second Hospital of Jilin University, Changchun, 130021, P. R. China. lbin99@jlu.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yiran Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "He Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ning Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiayi Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Bin Liu",
      "orcid": "0000-0002-7304-6806"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7tbz7yfb59cgs.bib",
  "cited_by": 0,
  "doi": "10.1186/s12964-026-03073-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13682045",
  "id": "7tbz7yfb59cgs",
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  "landing_url": "https://europepmc.org/article/MED/42897642",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "lcc",
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      "2807|Circadian rhythm and melatonin"
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  "pdf_url": "https://europepmc.org/articles/PMC13682045?pdf=render",
  "pmcid": "PMC13682045",
  "pmid": "42897642",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7tbz7yfb59cgs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897642",
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      "url": "https://europepmc.org/article/MED/42897642"
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    {
      "first_seen": "2026-10-30T13:46:14Z",
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      "url": "https://doi.org/10.1186/s12964-026-03073-x"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Circadian rhythm and melatonin",
      "subfield": "physiology"
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  ],
  "title": "Circadian clock and its potential as a therapy for ischemic heart disease.",
  "title_text": "Circadian clock and its potential as a therapy for ischemic heart disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:14Z",
  "url": "https://research.draconitic.com/paper/7tbz7yfb59cgs",
  "venue": "Cell communication and signaling : CCS",
  "versions": []
}