{
  "abstract": "Catenin alpha-like 1 (CTNNAL1) is an adhesion-related protein implicated in cellular plasticity; however, its involvement in cancer stem cell (CSC)-associated properties and epithelial-mesenchymal transition (EMT)-associated phenotypes in breast cancer remains unclear. In this study, we investigated the relationship of CTNNAL1 with CSC-associated properties and EMT-associated phenotypes in MDA-MB-231 breast cancer cells. CTNNAL1 expression increased under sphere-forming conditions together with CSC-associated markers, including CD44, aldehyde dehydrogenase 1 (ALDH1A1), and ALDH1A3. Silencing of CTNNAL1 reduced the expression of these markers and stemness-associated transcription factors, including Sox2, Oct4, and Nanog. CTNNAL1 knockdown also decreased sphere size and sphere-forming efficiency. Furthermore, CTNNAL1 depletion increased E-cadherin expression and decreased N-cadherin, vimentin, and EMT-associated transcription factors, including Snail, Slug, Twist, and ZEB1. CTNNAL1 knockdown also reduced cell migration and invasion. Collectively, these findings suggest that CTNNAL1 is associated with CSC-like properties and EMT-associated phenotypes in MDA-MB-231 breast cancer cells.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biotechnology, Yong In University, Yongin 17092, Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Min Su Kim",
      "orcid": "0009-0003-0925-6870"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin Young Jang",
      "orcid": "0009-0008-8594-4882"
    },
    {
      "affs": [
        0
      ],
      "name": "Rae-Kwon Kim",
      "orcid": "0000-0001-6607-4449"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7tcbmx1819qm6.bib",
  "cited_by": 0,
  "doi": "10.12717/dr.2026.30.3.135",
  "fulltext_url": "https://europepmc.org/articles/PMC13678312",
  "id": "7tcbmx1819qm6",
  "issns": [
    "2465-9525",
    "2465-9541"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898851",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Cells and Metastasis"
    ]
  ],
  "openalex": "W7222964719",
  "pdf_url": "https://europepmc.org/articles/PMC13678312?pdf=render",
  "pmcid": "PMC13678312",
  "pmid": "42898851",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7tcbmx1819qm6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898851",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898851"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Cells and Metastasis",
      "subfield": "oncology"
    }
  ],
  "title": "Catenin Alpha-Like 1 (CTNNAL1) Modulates Cancer Stem Cell-Associated Properties and Epithelial-Mesenchymal Transition (EMT)-Associated Phenotypes in MDA-MB-231 Breast Cancer Cells.",
  "title_text": "Catenin Alpha-Like 1 (CTNNAL1) Modulates Cancer Stem Cell-Associated Properties and Epithelial-Mesenchymal Transition (EMT)-Associated Phenotypes in MDA-MB-231 Breast Cancer Cells.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/7tcbmx1819qm6",
  "venue": "Development & reproduction",
  "versions": []
}