{
  "abstract": "Objectives: Up to 60 per cent of patients with enlarged vestibular aqueduct syndrome experience sudden hearing loss. This review analyses treatment options and outcomes when sudden hearing loss occurs.\n\nMethods: Embase, Ovid MEDLINE and Web of Science databases were the data sources. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered on PROSPERO. The number of patients, episodes, treatments, baseline hearing and change in hearing thresholds after intervention and return to baseline were extracted.\n\nResults: The final analysis included 60 episodes of hearing loss from 11 studies, from a search of 1,064 studies. The treatment groups were: 1, no treatment; 2, systemic steroids; 3, salvage hyperbaric oxygen therapy in steroid partial or non-responders. The hearing improvement across the groups was 9.1 per cent, 50 per cent and 89.5 per cent, respectively.\n\nConclusion: Enlarged vestibular aqueduct patients with sudden hearing loss may first be treated with systemic steroids. Salvage hyperbaric oxygen therapy can be considered in steroid non-responders to improve further chances of recovery.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology, KK Women’s and Children’s Hospital, Singapore",
    "Department of Otolaryngology–Head and Neck Surgery and Paediatric Surgery, Montreal Children’s Hospital, McGill University, Montreal, QC, Canada",
    "Hamilton College, Clinton, NY, USA",
    "Yong Loo Lin School of Medicine, National University of Singapore, Singapore"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ching Yee Chan",
      "orcid": "0000-0003-4537-1967"
    },
    {
      "affs": [
        2
      ],
      "name": "Joshua Nadler"
    },
    {
      "affs": [
        3
      ],
      "name": "Sheng Yep Brian Yeo"
    },
    {
      "affs": [
        0
      ],
      "name": "Xue Li Samantha Sim"
    },
    {
      "affs": [
        1
      ],
      "name": "Joshua Gurberg"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7tn771drjs8ec.bib",
  "cited_by": 1,
  "doi": "10.1017/s0022215126105088",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735498/",
  "id": "7tn771drjs8ec",
  "issns": [
    "0022-2151",
    "1748-5460"
  ],
  "landing_url": "https://doi.org/10.1017/s0022215126105088",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "2808|Vestibular and auditory disorders"
    ]
  ],
  "openalex": "W7163162028",
  "pdf_url": null,
  "pmcid": "PMC13735498",
  "pmid": "42227101",
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7tn771drjs8ec.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:10Z",
      "native_id": "PMC13735498",
      "source": "pmc",
      "url": "https://doi.org/10.1017/s0022215126105088"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Vestibular and auditory disorders",
      "subfield": "neurology"
    }
  ],
  "title": "Sudden hearing loss in enlarged vestibular aqueduct syndrome: a systematic review of treatment and outcomes",
  "title_text": "Sudden hearing loss in enlarged vestibular aqueduct syndrome: a systematic review of treatment and outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:10Z",
  "url": "https://research.draconitic.com/paper/7tn771drjs8ec",
  "venue": "The Journal of Laryngology and Otology",
  "versions": []
}