{
  "abstract": "Background: Focal lesions are one of the key factors contributing to brain atrophy in multiple sclerosis (MS) patients. This study aimed to investigate the associations between the different types of chronic lesions and gray matter atrophy in MS patients.\n\nMethods: The study recruited MS patients from two institutions, along with healthy controls (HCs). Lesions were classified into paramagnetic rim lesions (PRLs) and non-PRLs. Lesion volume, diffusion kurtosis imaging (DKI) parameters, brain volume (BV), gray matter volume (GMV), and cortical thickness (CT) were extracted. Differences between PRLs and non-PRLs, as well as between MS and HC groups, were analyzed. The associations between lesions and brain structure features were assessed using a general linear model.\n\nResults: The study included 46 relapsing-remitting multiple sclerosis (RRMS) patients and 31 HCs. A total of 940 chronic lesions were collected, of which 382 were PRLs (41%) and the remainder were non-PRLs. PRLs had larger volume and lower DKI parameters compared to non-PRLs. The MS group showed reduced GMV and CT compared to the HC group. The volume of all lesion types was negatively correlated with brain structure features, while some DKI parameters showed positive correlations. The Kr value of non-PRLs, the Kr value of whole lesions, and the volume of whole lesions were most strongly correlated with GMV, BV, and CT, respectively.\n\nConclusion: Both the volume and microstructural damage of chronic MS lesions are associated with gray matter atrophy. Contrary to expectations, the microstructural impairment of non-PRLs showed a stronger association with atrophy than that of the more destructive PRLs. This highlights the need to pay more attention to the role of non-PRLs in disease progression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, No.10 Qingyun South Street, Jinjiang District, Chengdu, Sichuan 610011 China",
    "Department of Radiology, The Traditional Chinese Medicine Hospital of Longquanyi, Chengdu, No. 222 Qingtaishan Road, Longquanyi District, Chengdu, Sichuan 610100 China",
    "Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016 China",
    "Department of Neurology, West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, No.10 Qingyun South Street, Jinjiang District, Chengdu, Sichuan 610011 China",
    "Department of Orthopedics, West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital, No.10 Qingyun South Street, Jinjiang District, Chengdu, Sichuan 610011 China",
    "Department of Radiology, West China Hospital Sichuan University Jintang Hospital, Jintang First People’s Hospital, No.886 Jinguang Road, Jintang County, Chengdu, 610400 China",
    "Department of Radiology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 12 Changjia Street, Fucheng District, Mianyang, Sichuan 621000 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hai Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Ping Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yongmei Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Tianfang Zeng"
    },
    {
      "affs": [
        3
      ],
      "name": "Liang Gong"
    },
    {
      "affs": [
        4
      ],
      "name": "Dandan Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhuowei Shi"
    },
    {
      "affs": [
        5
      ],
      "name": "Hao Xie"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Long Ye"
    },
    {
      "affs": [
        0
      ],
      "name": "Guangwen Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Li",
      "orcid": "0009-0006-4077-0984"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7tsn3dnxe5r2x.bib",
  "cited_by": 0,
  "doi": "10.1186/s12880-026-02656-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732966/",
  "id": "7tsn3dnxe5r2x",
  "issns": [
    "1471-2342"
  ],
  "landing_url": "https://doi.org/10.1186/s12880-026-02656-x",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2728|Multiple Sclerosis Research Studies"
    ]
  ],
  "openalex": "W7201873003",
  "pdf_url": null,
  "pmcid": "PMC13732966",
  "pmid": "42983665",
  "published": "2026-08-07",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7tsn3dnxe5r2x.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:51Z",
      "native_id": "PMC13732966",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12880-026-02656-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Multiple Sclerosis Research Studies",
      "subfield": "neurology"
    }
  ],
  "title": "Associations between different types of chronic lesions and gray matter atrophy in multiple sclerosis",
  "title_text": "Associations between different types of chronic lesions and gray matter atrophy in multiple sclerosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:51Z",
  "url": "https://research.draconitic.com/paper/7tsn3dnxe5r2x",
  "venue": "BMC Medical Imaging",
  "versions": []
}