{
  "abstract": "Background: In the elderly, ABO blood groups influence the risk of cardiovascular and thrombotic events, with blood group O consistently showing a more favorable risk profile. However, whether these differences affect physiological markers of vascular structure or subclinical metabolic traits in early adulthood remains poorly studied.\n\nMethods: In this cross-sectional study, cardiovascular disease-related biomarkers in serum, measures of vascular structure and function, pulse-wave velocity (PWV), augmentation index (AIx), carotid intima-media thickness (cIMT), and ABO blood groups were assessed in a sample of young, healthy subjects aged 18–26 years.\n\nResults: No statistically significant differences in PWV, AIx, or cIMT were identified across the different ABO blood groups. Conversely, the serum biomarkers showed distinct profiles. Individuals with blood group O presented with lower plasma concentrations of von Willebrand factor (vWF) compared to all non-O carriers (0.84 kIE/L vs. non-O, 1.09 kIE/L, p < 0.05). Furthermore, blood group O carriers demonstrated significantly lower fasting plasma glucose levels (4.96 mmol/L vs. 5.02 mmol/L, p = 0.02) and a trend toward lower fasting serum insulin levels (p = 0.07).\n\nConclusion: ABO blood groups were not associated with measures of vascular structure and function in young, healthy adults. Non-O blood groups were associated with higher vWF levels and altered glucose metabolism, suggesting that circulating cardiometabolic risk markers vary by blood group early in life.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden",
    "Department of Laboratory Medicine, Clinical Chemistry, Örebro University Hospital, Örebro, Sweden",
    "School of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kristina Stefansson",
      "orcid": "0000-0001-8690-2117"
    },
    {
      "affs": [
        0
      ],
      "name": "Gurdeep Chahal",
      "orcid": "0000-0001-9601-3057"
    },
    {
      "affs": [
        0
      ],
      "name": "Johan Hultdin",
      "orcid": "0000-0002-9599-0961"
    },
    {
      "affs": [
        0
      ],
      "name": "Torbjörn K. Nilsson"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Paul Pettersson-Pablo",
      "orcid": "0000-0001-8458-6448"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7tv0d4ptm47yj.bib",
  "cited_by": 0,
  "doi": "10.1186/s12872-026-06924-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715086/",
  "id": "7tv0d4ptm47yj",
  "issns": [
    "1471-2261"
  ],
  "landing_url": "https://doi.org/10.1186/s12872-026-06924-0",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2705|Cardiovascular Health and Disease Prevention"
    ]
  ],
  "openalex": "W7223926237",
  "pdf_url": null,
  "pmcid": "PMC13715086",
  "pmid": "42946986",
  "published": "2026-10-27",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7tv0d4ptm47yj.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:28Z",
      "native_id": "PMC13715086",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12872-026-06924-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Health and Disease Prevention",
      "subfield": "cardiovascular"
    }
  ],
  "title": "ABO blood groups in relation to biomarkers of vascular structure and function in young, healthy adults – the LBA study",
  "title_text": "ABO blood groups in relation to biomarkers of vascular structure and function in young, healthy adults – the LBA study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:28Z",
  "url": "https://research.draconitic.com/paper/7tv0d4ptm47yj",
  "venue": "BMC Cardiovascular Disorders",
  "versions": []
}