{
  "abstract": "目的研究磁共振成像（MRI）联合血清甘油-3-磷酸脱氢酶1-样酶（GPD1L）、纺锤体卷曲螺旋蛋白1（SPDL1）对食管癌诊断的临床价值。方法选取2022年1月至2024年12月康复大学青岛中心医院收治的148例疑似食管癌患者为研究对象，活检分为患癌组（食管癌）85例、病变组（食管良性病变）63例。另选取同期康复大学青岛中心医院体检健康者90例为对照组。获取MRI参数，利用MRI检查和血清GPD1L、SPDL1及其联合诊断食管癌，比较各种诊断方式的价值及其与活检相比的一致性。比较食管癌患者不同临床特征下血清GPD1L、SPDL1的表达变化。结果患癌组转运常数（Ktrans）、速率常数（Kep）、细胞外血管外间隙容积比（Ve）高于病变组（P<0.05）。对照组、病变组、患癌组血清GPD1L水平依次降低，SPDL1水平依次升高（P<0.05）。ROC分析显示，MRI、GPD1L、SPDL1联合诊断食管癌的灵敏度、高于三者单独诊断的灵敏度（P<0.05）。Kappa一致性分析显示，与单独诊断方式相较，MRI、GPD1L、SPDL1联合与活检的一致性较高。在不同分化程度、TNM分期以及淋巴结转移条件下血清GPD1L、SPDL1表达发生显著变化，低分化、Ⅲ~Ⅳ期、有淋巴结转移患者血清GPD1L表达低于中高分化、Ⅰ~Ⅱ期、无淋巴结转移，SPDL1表达高于中高分化、Ⅰ~Ⅱ期、无淋巴结转移（P<0.05）。结论食管癌患者血清GPD1L mRNA表达下降、SPDL1 mRNA表达上升，MRI、GPD1L、SPDL1均能作为诊断食管癌的重要方式，且MRI、GPD1L、SPDL1联合检测能明显提升诊断灵敏度，可拓展应用于临床。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "张敏"
    },
    {
      "name": "孙浩淼"
    },
    {
      "name": "孙海波"
    },
    {
      "name": "朱超"
    },
    {
      "name": "林秋菊"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7v45r9znhfwcd.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.006",
  "id": "7v45r9znhfwcd",
  "issns": [
    "1007-4287"
  ],
  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.006",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/7v45r9znhfwcd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:48Z",
      "native_id": "de15b15039d04944b4531e76894454ca",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.006"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "MRI联合血清GPD1L、SPDL1诊断食管癌的临床价值研究",
  "title_text": "MRI联合血清GPD1L、SPDL1诊断食管癌的临床价值研究",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:48Z",
  "url": "https://research.draconitic.com/paper/7v45r9znhfwcd",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}