{
  "abstract": "Motor maintenance in Parkinson’s disease (PD) requires cooperation between cognitive and motor function. This study aimed to explore the manifestation and structural correlates of cognitive influence on PD motor. Forty-four normal controls (NCs), 265 probable isolated rapid eye movement behavior disorders patients (pRBD) and 176 PD patients were evaluated with quantitative motor tests. Subject performance under different task complexities was explored. Some subjects were further examined with magnetic resonance imaging (MRI) and analyzed with cognitive-motor interference (CMI) model concentrated on the subcortical regions. We demonstrated that PD patients had difficulty in performing tasks involving both upper and lower limbs, irrespective of task complexities; and as task became harder, they performed worse. However, during early parkinsonian period, subjects with higher educational attainment were associated with less severe motor dysfunction. Further, our findings revalidated the vital role of substantia nigra played in PD pathophysiology and explored the complex and variable association between subcortical structures and CMI across prodromal and clinical stages of parkinsonism.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China",
    "Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jingjing Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingwen Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Cheng Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojun Guan"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoting Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenqing Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaqi Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianmei Qin"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojie Duanmu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qianshi Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Weijin Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Zihao Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Baorong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojun Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Minming Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7v49ea0s82rbj.bib",
  "cited_by": 0,
  "doi": "10.1038/s41531-026-01464-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724707/",
  "id": "7v49ea0s82rbj",
  "issns": [
    "2373-8057"
  ],
  "landing_url": "https://doi.org/10.1038/s41531-026-01464-y",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2728|Parkinson's Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7167734150",
  "pdf_url": "https://www.nature.com/articles/s41531-026-01464-y_reference.pdf",
  "pmcid": "PMC13724707",
  "pmid": "42420279",
  "published": "2026-07-08",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/7v49ea0s82rbj.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:14Z",
      "native_id": "PMC13724707",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41531-026-01464-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Parkinson's Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "The clinical manifestation and neural correlates of cognitive-motor interference in Parkinson’s disease",
  "title_text": "The clinical manifestation and neural correlates of cognitive-motor interference in Parkinson’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:26Z",
  "url": "https://research.draconitic.com/paper/7v49ea0s82rbj",
  "venue": "NPJ Parkinson's Disease",
  "versions": []
}