{
  "abstract": "Biological function and risk coexisted in the vigorous development of nanomedicine. Its toxic accumulation risk in the human body and other health hazards also made people increasingly worried about its safety risk. In this study, the micro-morphology of multi-component self-assembly in Rhei Radix et Rhizoma (RR)- Coptidis Rhizoma (CR) were regulated by thermodynamic method to realize the difference of diarrhea effect. The nano-morphology of the decoction was transformed from fiber network (cold mixing decoction (CM)) to spherical particles (hot mix reheating decoction (HMR)) by reheating treatment. This morphological transformation was achieved by altering the arrangement of key components such as emodin (Emo) and berberine (Ber) from a staggered assembly to a face-to-face assembly, which increased the interaction area and interaction force. The fiber network in CM exhibited indiscriminate coverage, causing severe damage to intestinal probiotics. This disruption promoted tyrosine metabolism of Enterobacteriaceae, resulting in large area proliferation of pathogenic bacteria and subsequent diarrhea. In contrast, the spheroid particles of HMR selectively attached to bacteria, thereby reducing toxicity to intestinal bacteria. By promoting tryptophan metabolism, intestinal homeostasis and intestinal barrier of HMR were maintained to prevent the toxic of diarrhea. This study provides a novel strategy for the toxic study of nanomedicine and offers reference for rational use of nanomedicine in clinic.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China",
    "National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases, Beijing University of Chinese Medicine, Beijing, 100105, China; Corresponding author.",
    "School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoyu Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jichang Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Yihang Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Liuyang Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ji Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Xuemei Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Penglong Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7vaeny9df8pgm.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jpha.2026.101650",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S209517792600105X",
  "id": "7vaeny9df8pgm",
  "issns": [
    "2095-1779",
    "2214-0883"
  ],
  "landing_url": "https://doi.org/10.1016/j.jpha.2026.101650",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2707|Traditional Chinese Medicine Analysis"
    ]
  ],
  "openalex": "W7161262517",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7vaeny9df8pgm.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:02Z",
      "native_id": "053812b2c3b643d6af83b6a30acf16a2",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jpha.2026.101650"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RM1-950",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Thermodynamically-driven the transformation of supramolecular morphology and nanoscale accompanied with the toxic changes from herbal medicine",
  "title_text": "Thermodynamically-driven the transformation of supramolecular morphology and nanoscale accompanied with the toxic changes from herbal medicine",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:02Z",
  "url": "https://research.draconitic.com/paper/7vaeny9df8pgm",
  "venue": "Journal of Pharmaceutical Analysis",
  "versions": []
}