{
  "abstract": "Background\n\nThis study evaluated long-term survival outcomes in breast cancer patients aged ≥80 years, focusing on how prognostic factors change when competing mortality risks are considered.Methods\n\nWe retrospectively analyzed 106 octogenarian breast cancer patients treated between 2013 and 2023. Endocrine therapy was evaluated as a treatment-related prognostic factor. Treatment-related prognostic factors were evaluated using multivariable Cox proportional hazards and Fine-Gray competing-risks models.Results\n\nThe median age was 82 years, and the median follow-up time was 27.5 months (range, 6-99 months). In the multivariable Cox proportional hazards, biopsy compared with surgery (HR, 0.56; p = 0.037), presence of endocrine therapy (HR, 0.38; p = 0.003), and CCI ≥ 8 (HR, 9.96; p < 0.001) were independently associated with OS. In the Fine-Gray model, the associations of surgical procedure (p = 0.120) and endocrine therapy (p = 0.081) with breast cancer-specific mortality were no longer statistically significant. CCI ≥ 8 remained significantly associated with breast cancer-specific mortality (sHR, 3.76; 95% CI, 1.52-9.31; p = 0.004).Conclusions\n\nIn octogenarian breast cancer patients, surgery and endocrine therapy were associated with improved OS, but their associations with breast cancer-specific mortality were attenuated after accounting for competing risks. High CCI emerged as the most robust prognostic factor. These findings support incorporating comorbidity burden and competing-risks assessment into individualized treatment decisions in this population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, University of Health Sciences Turkey, Istanbul Training and Research Hospital, 34098 Istanbul, Turkey.",
    "Department of Medical Oncology, University of Health Sciences Turkey, Istanbul Training and Research Hospital, 34098 Istanbul, Turkey.",
    "Department of Nuclear Medicine, University of Health Sciences Turkey, Istanbul Training and Research Hospital, 34098 Istanbul, Turkey.",
    "Department of General Surgery, University of Health Sciences Turkey, Istanbul Training and Research Hospital, 34098 Istanbul, Turkey.",
    "Department of General Surgery, School of Medicine, Bahçeşehir University, 34734 Istanbul, Turkey.",
    "Department of Pathology, University of Health Sciences Turkey, Istanbul Training and Research Hospital, 34098 Istanbul, Turkey.",
    "Department of Radiology, University of Health Sciences Turkey, Istanbul Training and Research Hospital, 34098 Istanbul, Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Özlem Mermut",
      "orcid": "0000-0002-5449-7361"
    },
    {
      "affs": [
        0
      ],
      "name": "Berrin Yalçın"
    },
    {
      "affs": [
        1
      ],
      "name": "Rıza Umar Gürsu"
    },
    {
      "affs": [
        2
      ],
      "name": "Esra Arslan",
      "orcid": "0000-0002-9222-8883"
    },
    {
      "affs": [
        3
      ],
      "name": "Bülent Akçe"
    },
    {
      "affs": [
        4
      ],
      "name": "Didem Can Trabulus"
    },
    {
      "affs": [
        5
      ],
      "name": "Semiha Battal Havare"
    },
    {
      "affs": [
        6
      ],
      "name": "Serap Karabıyık"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7vb8j76t2gjdz.bib",
  "cited_by": 0,
  "doi": "10.3390/curroncol33100636",
  "fulltext_url": "https://europepmc.org/articles/PMC13702921",
  "id": "7vb8j76t2gjdz",
  "issns": [
    "1198-0052",
    "1718-7729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930203",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Breast Cancer Treatment Studies"
    ]
  ],
  "openalex": "W7223070482",
  "pdf_url": "https://europepmc.org/articles/PMC13702921?pdf=render",
  "pmcid": "PMC13702921",
  "pmid": "42930203",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7vb8j76t2gjdz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930203",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930203"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Breast Cancer Treatment Studies",
      "subfield": "oncology"
    }
  ],
  "title": "Cancer-Specific Survival in Octogenarian Breast Cancer Patients: A Competing Risk Analysis of Prognostic Factors.",
  "title_text": "Cancer-Specific Survival in Octogenarian Breast Cancer Patients: A Competing Risk Analysis of Prognostic Factors.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/7vb8j76t2gjdz",
  "venue": "Current oncology (Toronto, Ont.)",
  "versions": []
}