{
  "abstract": "Domestication of crops, such as rice, has resulted in the loss of beneficial root-associated microbiota central to plant nitrogen-use efficiency. Whether these microbes can be inherited through hybridization of wild and cultivated plants and the host genes involved is unclear. Here we used two recombinant inbred line populations, derived from cultivated rice (Oryza sativa) and its wild relative Oryza rufipogon to map host quantitative trait loci associated with core bacterial taxa. Integrating microbiome profiling, quantitative trait loci mapping, population genomics and transgenic validation, we identified 113 candidate plant genes. The receptor-like kinase-encoding gene OsRLK, found predominantly in wild rice, was significantly associated with Acinetobacter, which enhances plant nitrogen uptake. Knockout and overexpression of OsRLK, inoculated with an Acinetobacter synthetic community, validated their role in nitrogen-use efficiency. In field trials, the overexpression line significantly increased yield-related traits. These findings establish the genetic basis of microbiome re-domestication and provide a framework for microbiome-guided breeding of nutrient-efficient crops.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, China",
    "Department of Microbial Ecology, Netherlands Institute of Ecology NIOO-KNAW, Wageningen, the Netherlands",
    "Rice National Engineering Research Center (Nanchang), Rice Research Institute, Jiangxi Academy of Agricultural Sciences, Nanchang, China",
    "Key Laboratory of Straw Comprehensive Utilization and Black Soil Conservation, Jilin Agricultural University, Changchun, Jilin China",
    "Ecology and Biodiversity, Institute of Environmental Biology, Utrecht University, Utrecht, the Netherlands",
    "College of Landscape Architecture, Changchun University, Changchun, China",
    "Institute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX USA",
    "School of Agriculture and Biological Technique, Liaocheng University, Liaocheng, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jingjing Chang"
    },
    {
      "affs": [
        2
      ],
      "name": "Dianwen Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zongmu Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingnan Pang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hengfei Zhang"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Changji Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yuanbo Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Sun"
    },
    {
      "affs": [
        3
      ],
      "name": "Jianfeng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiqiang Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Aizhen Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiangnan Li",
      "orcid": "0000-0003-0417-9151"
    },
    {
      "affs": [
        2
      ],
      "name": "Dazhou Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Hongping Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuewen Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Enze Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Lam-Son Phan Tran",
      "orcid": "0000-0001-9883-9768"
    },
    {
      "affs": [
        2
      ],
      "name": "Jilin Wang",
      "orcid": "0000-0001-7858-1683"
    },
    {
      "affs": [
        1
      ],
      "name": "Jos M. Raaijmakers",
      "orcid": "0000-0003-1608-6614"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Chunjie Tian",
      "orcid": "0000-0003-1792-6005"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Eiko E. Kuramae",
      "orcid": "0000-0001-6701-8668"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7vgf7dyf5zn9v.bib",
  "cited_by": 0,
  "doi": "10.1038/s41564-026-02498-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13739750/",
  "id": "7vgf7dyf5zn9v",
  "issns": [
    "2058-5276"
  ],
  "landing_url": "https://doi.org/10.1038/s41564-026-02498-x",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1110|Plant-Microbe Interactions and Immunity"
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  "openalex": "W7214973470",
  "pdf_url": "https://www.nature.com/articles/s41564-026-02498-x.pdf",
  "pmcid": "PMC13739750",
  "pmid": "42816582",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7vgf7dyf5zn9v.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:21:09Z",
      "native_id": "PMC13739750",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41564-026-02498-x"
    }
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant-Microbe Interactions and Immunity",
      "subfield": "plant-biology"
    }
  ],
  "title": "Wild rice locus enables microbiome re-domestication for enhanced nitrogen-use efficiency",
  "title_text": "Wild rice locus enables microbiome re-domestication for enhanced nitrogen-use efficiency",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:21:09Z",
  "url": "https://research.draconitic.com/paper/7vgf7dyf5zn9v",
  "venue": "Nature Microbiology",
  "versions": []
}