{
  "abstract": "Background: Placental growth factor (PlGF) contributes to first-trimester screening algorithms for preeclampsia, but its prognostic performance as an isolated biomarker in routine Chinese care is uncertain.\n\nMethods: We performed a retrospective, single-centre cohort study among pregnancy episodes recorded in a hospital PlGF workbook. Pregnancy episodes were deduplicated, PlGF values were traced to source laboratory cells, and hypertensive disorders of pregnancy (HDP) were ascertained using unvalidated free-text discharge-diagnosis keywords. The primary operational window was 9 + 0 to 13 + 6 weeks; 11 + 0 to 13 + 6 weeks was evaluated separately. We compared PlGF with a parsimonious maternal-characteristics model containing age, pre-pregnancy body mass index (BMI), and nulliparity.\n\nResults: From 405 source rows, 380 pregnancy episodes were resolved; 310 met the primary criteria, including 27 HDP events (11 cases of preeclampsia and 16 of gestational hypertension). PlGF alone had an area under the curve (AUC) of 0.633 (95% bootstrap CI 0.523–0.738), and internally derived PlGF multiple of the median (MoM) had an AUC of 0.636 (0.533–0.740). In 308 complete records, the maternal-characteristics model had an apparent AUC of 0.740 (0.635–0.837), while adding log10(PlGF) yielded an AUC of 0.748 (0.638–0.849); paired ΔAUC was 0.009 (95% CI −0.019 to 0.037).\n\nConclusion: The findings are consistent with a modest association between lower first-trimester PlGF and subsequent HDP, but they do not support isolated clinical use or a deployable prediction model.",
  "abstract_shown": true,
  "affiliations": [
    "Hangzhou Fuyang Women And Children Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lingling Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Minxia Chai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Xia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7vjg4wahq4qyn.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1960406",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716667/?tool=EBI",
  "id": "7vjg4wahq4qyn",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1960406/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2729|Pregnancy and preeclampsia studies"
    ]
  ],
  "openalex": "W7222206518",
  "pdf_url": "https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1960406/pdf",
  "pmcid": "PMC13716667",
  "pmid": "42959230",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7vjg4wahq4qyn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1960406",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1960406/full"
    },
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "PMC:PMC13716667",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13716667"
    },
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42959230",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959230"
    },
    {
      "first_seen": "2026-11-01T12:23:55Z",
      "native_id": "PMC13716667",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fendo.2026.1960406"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Pregnancy and preeclampsia studies",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Real-world discrimination and incremental value of first-trimester placental growth factor for hypertensive disorders of pregnancy: a retrospective Chinese cohort",
  "title_text": "Real-world discrimination and incremental value of first-trimester placental growth factor for hypertensive disorders of pregnancy: a retrospective Chinese cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:09Z",
  "url": "https://research.draconitic.com/paper/7vjg4wahq4qyn",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}