{
  "abstract": "Carbohydrates are essential molecules involved in a wide range of biological processes. While their structural representation in the Protein Data Bank (PDB) has been hindered due to their highly diverse and flexible nature, advancements on X-ray crystallography and CryoEM are accelerating the obtaining of their experimental structures, which in turn supports improved analyses of their structural properties, such as the role of their non-chair conformations on biological processes. In this context, the current work provides a comprehensive and up to date overview of carbohydrate structures within the PDB through classification, quantification, and characterization of monosaccharides and glycan chains, incorporating Cremer-Pople puckering coordinates to evaluate pyranose conformations. Our findings show that, even with a steep increase in CryoEM structures including more complex oligosaccharides, carbohydrate data remains concentrate dinsmallglycanchains, with a about 4% of non-chair conformation sintopresolution structures. Free energy landscapes for the pyranose ring in the presence and absence of nine different binding proteins, including both enzymes and non-enzymes, reinforce the preferred stability of chairs and the rarity of conformational induction upon binding.",
  "abstract_shown": true,
  "affiliations": [
    "Brazilian Center for Research in Energy and Materials"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "D. S. Lima"
    },
    {
      "name": "V. A. Cabral"
    },
    {
      "affs": [
        0
      ],
      "name": "H. Verli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7vnt62rwwcg7j.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.30.755651",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755651v1.full",
  "id": "7vnt62rwwcg7j",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755651v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biophysics"
    ],
    [
      "openalex",
      "1604|Crystal structures of chemical compounds"
    ]
  ],
  "openalex": "W7220672043",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755651v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7vnt62rwwcg7j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:19Z",
      "native_id": "10.64898/2026.09.30.755651",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755651v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biophysics",
      "subfield": "biophysics"
    }
  ],
  "title": "Are carbohydrate ring distortions determined by biology or crystallography? The impact of experimental conditions on structural data",
  "title_text": "Are carbohydrate ring distortions determined by biology or crystallography? The impact of experimental conditions on structural data",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:19Z",
  "url": "https://research.draconitic.com/paper/7vnt62rwwcg7j",
  "venue": "bioRxiv",
  "versions": []
}