{
  "abstract": "Binary SiO 2 -CaO bioactive glass nanoparticles (NPs) are synthesized as the elementary bricks of freeze-cast (FC) macroscopic scaffolds envisioned for human mandible bone transplants. In-situ X-ray scattering at ultra-small, small and wide angles (USAXS/SAXS/WAXS) was used to monitor the successive steps involved in the production of the NPs and their stability in suspensions prior to FC. Time-resolved scattering (TR-SAXS) revealed the growth mechanisms of nanosilicate cores in aqueous solutions. Quantitative analysis in absolute scale of the intensity demonstrates that subsequent calcium incorporation strongly modifies the colloidal interactions via the formation of hydrated Ca²⁺/NO₃⁻ interfacial layers, that promote partial mass-fractal aggregation from reduced electrostatic repulsion. Upon transfer to organic FC solvents such as dimethyl carbonate, further ion condensation favors tenuous rod-like aggregation even for pure silica NPs. SAXS analysis combined with analytical centrifugation indicate that aggregation controls the homogeneity of the FC suspensions by greatly accelerating sedimentation, which can be mitigated by addition of free PDLLA chains. Operando phase-contrast X-ray computed tomography prior to FC further reveals the spatial NPs and aggregates distribution, that strongly influence the properties of the final scaffold network. This comprehensive multiscale framework linking nanoparticle synthesis and interactions, colloidal stability and FC suspensions homogeneity, provides new insights for the rational design of freeze-cast nanocomposite scaffolds.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Alexandra Pierron"
    },
    {
      "name": "Isabelle Morfin"
    },
    {
      "name": "Prescillia Lagarrigue"
    },
    {
      "name": "Ludovic Broche"
    },
    {
      "name": "William Chèvremont"
    },
    {
      "name": "Thomas Bizien"
    },
    {
      "name": "Vincent Darcos"
    },
    {
      "name": "Jérémy Soulié"
    },
    {
      "name": "Guillaume Brotons"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7vy5csd8gsk9m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.colsurfa.2026.141005",
  "fulltext_url": null,
  "id": "7vy5csd8gsk9m",
  "issns": [
    "0927-7757",
    "1873-4359"
  ],
  "landing_url": "https://hal.science/hal-05854713v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "0.phys"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "0.spi"
    ],
    [
      "hal",
      "1.phys.cond"
    ],
    [
      "hal",
      "1.phys.meca"
    ],
    [
      "hal",
      "1.sdv.tox"
    ],
    [
      "hal",
      "1.spi.mat"
    ],
    [
      "hal",
      "2.phys.cond.cm-ms"
    ],
    [
      "hal",
      "2.phys.meca.mema"
    ],
    [
      "hal",
      "2.sdv.tox.eco"
    ],
    [
      "openalex",
      "2204|Bone Tissue Engineering Materials"
    ]
  ],
  "openalex": "W7165184826",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7vy5csd8gsk9m.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:44Z",
      "native_id": "hal-05854713",
      "source": "hal",
      "url": "https://hal.science/hal-05854713v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "chemistry",
      "origin": "hal:0.chim",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.tox",
      "subfield": "pharmacology-toxicology"
    },
    {
      "field": "physics",
      "origin": "hal:1.phys.cond",
      "subfield": "condensed-matter"
    }
  ],
  "title": "Binary SiO2-CaO bioactive glass nanoparticles synthesis and colloidal stability investigated via in-situ SAXS for freeze-cast scaffolds",
  "title_text": "Binary SiO2-CaO bioactive glass nanoparticles synthesis and colloidal stability investigated via in-situ SAXS for freeze-cast scaffolds",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:49Z",
  "url": "https://research.draconitic.com/paper/7vy5csd8gsk9m",
  "venue": "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
  "versions": []
}