{
  "abstract": "Introduction\n\nGut microbiota has been implicated in bone metabolism, but whether a diet supporting gut microbial health is associated with fracture prevalence in older women remains unclear. This study aimed to examine the association between the dietary index for gut microbiota (DI-GM) and fracture prevalence in women aged 50 years and older.Methods\n\nWe analyzed cross-sectional data from five NHANES cycles, including 6,318 women aged 50 years and older (mean age 63.8 ± 9.6 years). DI-GM scores were derived from 24-h dietary recalls based on 13 dietary components. Self-reported hip, wrist, or spine fracture was the outcome (863 women, 13.7%). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Weighted logistic regression and exploratory mediation analyses were performed.Results\n\nHigher DI-GM scores were associated with lower odds of fragility fracture (OR = 0.93, 95% CI: 0.88-1.00, p = 0.035) and any fracture (Model 3: OR = 0.96, 95% CI: 0.92-0.99, p = 0.045). Neither femoral neck nor spinal BMD significantly mediated these associations. In a small exploratory pilot cohort (n = 12), DI-GM scores were positively correlated with spinal BMD (R = 0.82, p = 0.0011).Discussion\n\nHigher DI-GM scores were associated with lower fracture prevalence in women aged 50 years and older, although BMD did not significantly mediate this association. Given the cross-sectional design and the small pilot sample, these findings should be considered exploratory and require confirmation in larger prospective studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cervicodynia/Omalgia/Lumbago/Sciatica, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, China.",
    "College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
    "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.",
    "Department of Foot and Ankle Surgery, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ji Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yunping Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Zihao Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Xingming Ning"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiongxia Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Guo"
    },
    {
      "affs": [
        1
      ],
      "name": "Luming Qi"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhangmeng Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7w21wd4ahhxbk.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1933908",
  "fulltext_url": "https://europepmc.org/articles/PMC13680436",
  "id": "7w21wd4ahhxbk",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903176",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2732|Bone health and osteoporosis research"
    ]
  ],
  "openalex": "W7220649998",
  "pdf_url": "https://europepmc.org/articles/PMC13680436?pdf=render",
  "pmcid": "PMC13680436",
  "pmid": "42903176",
  "published": "2026-10-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7w21wd4ahhxbk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903176",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903176"
    },
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1933908",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1933908/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Bone health and osteoporosis research",
      "subfield": "surgery"
    }
  ],
  "title": "Association between the dietary index for gut microbiota and fracture prevalence among women aged 50 years and older: a NHANES-based study with a preliminary exploratory pilot analysis.",
  "title_text": "Association between the dietary index for gut microbiota and fracture prevalence among women aged 50 years and older: a NHANES-based study with a preliminary exploratory pilot analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:22Z",
  "url": "https://research.draconitic.com/paper/7w21wd4ahhxbk",
  "venue": "Frontiers in public health",
  "versions": []
}