{
  "abstract": "Vascular smooth muscle cell (VSMC) heterogeneity drives region-specific aortic pathologies, yet the roles of somite-derived lineages remain unclear. Utilizing Myf5 and MyoD lineage tracing alongside a smooth muscle-specific Myf5 conditional knockout model, we show that Myf5-derived cells selectively populate the thoracic aortic media, whereas the MyoD lineage completely spares large arteries. Early embryonic Myf5 deletion suppressed embryonic VSMC proliferation and downregulated α-SMA, reduced the synthesis of elastic, establishing its necessity in aortic morphogenesis. Upon in vitro ox-LDL challenge and calcification induction, the non-Myf5 lineage primarily drives excessive proliferation and osteogenic transdifferentiation, whereas Myf5 lineage VSMCs exhibit remarkable phenotypic stability and resistance to PDGF-BB-induced dedifferentiation compared to their non-Myf5 counterparts. Collectively, our findings demonstrate a strict lineage divergence between Myf5 and MyoD, suggesting that Myf5 lineage cells play an important role in maintaining aortic integrity, and uncover a lineage-imprinted plasticity that explains regional vascular heterogeneity.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.",
    "Department of Cardiology, Huadong Hospital, Fudan University, Shanghai 200040, China.",
    "Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital, Fudan University, Shanghai 200040, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Donghua Hu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Kun Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Xifeng Chang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Xi Hu",
      "orcid": "0009-0007-0930-5299"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongjin Chen",
      "orcid": "0009-0002-1820-2244"
    },
    {
      "affs": [
        1
      ],
      "name": "Xingrong Zhai"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinkai Qu"
    },
    {
      "affs": [
        2
      ],
      "name": "Lei Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Cheng-Chao Ruan"
    },
    {
      "affs": [
        1
      ],
      "name": "Kailei Shi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7w3j4p6jc9sqw.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198594",
  "fulltext_url": "https://europepmc.org/articles/PMC13664892",
  "id": "7w3j4p6jc9sqw",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883840",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Atherosclerosis and Cardiovascular Diseases"
    ]
  ],
  "openalex": "W7214287882",
  "pdf_url": "https://europepmc.org/articles/PMC13664892?pdf=render",
  "pmcid": "PMC13664892",
  "pmid": "42883840",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7w3j4p6jc9sqw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883840",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883840"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Atherosclerosis and Cardiovascular Diseases",
      "subfield": "immunology"
    }
  ],
  "title": "Myf5 Progenitors Define the Lineage Identity of Somitic Vascular Smooth Muscle Cells.",
  "title_text": "Myf5 Progenitors Define the Lineage Identity of Somitic Vascular Smooth Muscle Cells.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/7w3j4p6jc9sqw",
  "venue": "International journal of molecular sciences",
  "versions": []
}