{
  "abstract": "During the 2010s, Escherichia coli ST131 clade A tested sensitive to most antibiotics. In the 2020s, Europe experienced outbreaks of fluoroquinolone-resistant ST131-A that contained CTX-M β-lactamases and OXA-48-like carbapenemases. We investigated the acquisition of different antimicrobial resistance determinants in the emergence of multidrug-resistant (MDR) ST131-A. Phylogenetic analysis and Bayesian inference were utilized to define subclades and clusters (within subclades) and investigate the evolutionary history of ST131-A, using sequenced genomes and publicly available genomic data ( n =2,905). ST131-A consisted of five dominant subclades and ten frequent clusters, representing 93 and 83% of the total population, respectively. The sampled most recent common ancestors of the dominant subclades dated mainly to the 1990s. Several MDR clusters linked with diverse quinolone resistance-determining region mutations, CTX-M and OXA-48-like genes diversified during the 2000s. The distribution and mobile genetic elements linked with bla CTX-M-14 , bla CTX-M-15 and bla CTX-M-27 differed among ST131-A subclades and clusters across geographic locations. Three ST131-A clusters belonging to different subclades and carrying bla OXA-48 and bla OXA-244 in distinct genetic contexts were associated with the recent European dissemination. The identification of MDR ST131-A subclades and clusters with divergent molecular architectures emerging independently across regions highlights the challenges for public health surveillance and control efforts.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Yasufumi Matsumura"
    },
    {
      "name": "Gisele Peirano"
    },
    {
      "name": "Pierre Bogaerts"
    },
    {
      "name": "Te-Din Huang"
    },
    {
      "name": "Bogdan I. Iorga"
    },
    {
      "name": "Miki Nagao"
    },
    {
      "name": "Johann D.D. Pitout"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7w8jhb3zdkmjs.bib",
  "cited_by": 0,
  "doi": "10.1099/mgen.0.001858",
  "fulltext_url": null,
  "id": "7w8jhb3zdkmjs",
  "issns": [
    "2057-5858",
    "2057-5858"
  ],
  "landing_url": "https://hal.science/hal-05787188v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7220843207",
  "pdf_url": "https://hal.science/hal-05787188/document",
  "pmcid": null,
  "pmid": "42842301",
  "published": "2026-10-07",
  "publisher": "Society for General Microbiology",
  "ris": "https://research.draconitic.com/paper/7w8jhb3zdkmjs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:51Z",
      "native_id": "hal-05787188",
      "source": "hal",
      "url": "https://hal.science/hal-05787188v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Genomic global epidemiology and evolution of Escherichia coli ST131 clade A",
  "title_text": "Genomic global epidemiology and evolution of Escherichia coli ST131 clade A",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:51Z",
  "url": "https://research.draconitic.com/paper/7w8jhb3zdkmjs",
  "venue": "Microbial Genomics",
  "versions": []
}