{
  "abstract": "Background\n\nChronic subdural haematoma (cSDH) is common in older adults, and medication exposures may influence postoperative outcomes. We assessed whether pre-surgery statin use is associated with short- and long-term outcomes.Methods\n\nWe conducted a nationwide registry study of adults undergoing surgical evacuation of traumatic or non-traumatic cSDH (6/2004-12/2018) in Finnish university hospitals. Pre-surgery statin use was defined from national prescription records using a pill-counting approach. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 30-day reoperation and length of hospital stay. Tertiary outcomes were 1-year mortality and reoperation. Mortality was analysed using Cox regression; reoperation with Fine-Gray models accounting for competing risk of death.Results\n\nThe cohort included 9001 patients, of whom 2450 (27.2%) used statins. Thirty-day mortality was 3.3% in statin users and 4.5% in non-users, with lower adjusted mortality among statin users (HR 0.57; 95% CI 0.44-0.73). Reoperation within 30 days (n = 897) was similar between groups (sub-distribution HR 1.08; 95% CI 0.97-1.21). Hospital stay was shorter in statin users (22.1 ± 62.7 vs 26.3 ± 77.5 days; adjusted P = .002). At 1 year, mortality remained lower in statin users (13.3% vs 15.4%; HR 0.66; 95% CI 0.58-0.75), with no difference in reoperation (sub-distribution HR 1.09; 95% CI 0.96-1.22).Conclusion\n\nIn this nationwide cohort of surgically treated cSDH patients, pre-surgery statin use was associated with lower short- and long-term mortality and shorter hospital stay, while reoperation rates were similar between statin users and non-users.",
  "abstract_shown": true,
  "affiliations": [
    "Neurocenter, Department of Neurosurgery, Turku University Hospital, Turku, Finland.",
    "Neurosurgery, Clinical Neurosciences, University of Turku, Turku, Finland.",
    "Institute of Biomedicine, University of Turku, Turku, Finland.",
    "Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.",
    "Neurocenter, Department of Neurology, Turku University Hospital, Turku, Finland.",
    "Neurology, Clinical Neurosciences, University of Turku, Turku, Finland.",
    "Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.",
    "Department of Neurosurgery, Tampere University Hospital, Tampere University, Tampere, Finland.",
    "Clinical Research Center, Turku University Hospital, Turku, Finland.",
    "Heart Centre, Turku University Hospital and University of Turku, Turku, Finland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jussi P Posti",
      "orcid": "0000-0002-5925-5193"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Aleksi Tornio",
      "orcid": "0000-0001-5713-5692"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Jori O Ruuskanen"
    },
    {
      "affs": [
        6
      ],
      "name": "Rahul Raj",
      "orcid": "0000-0003-4243-9591"
    },
    {
      "affs": [
        7
      ],
      "name": "Teemu Luoto"
    },
    {
      "affs": [
        6
      ],
      "name": "Pihla Tommiska",
      "orcid": "0000-0002-7418-1946"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Ville Kytö",
      "orcid": "0000-0002-4521-1093"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7wb1xaqvqz4k9.bib",
  "cited_by": 0,
  "doi": "10.1093/ageing/afag296",
  "fulltext_url": "https://europepmc.org/articles/PMC13688349",
  "id": "7wb1xaqvqz4k9",
  "issns": [
    "0002-0729",
    "1468-2834"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910913",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Neurosurgical Procedures and Complications"
    ]
  ],
  "openalex": "W7223179932",
  "pdf_url": "https://europepmc.org/articles/PMC13688349?pdf=render",
  "pmcid": "PMC13688349",
  "pmid": "42910913",
  "published": "2026-08-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7wb1xaqvqz4k9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910913",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910913"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Neurosurgical Procedures and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study.",
  "title_text": "Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/7wb1xaqvqz4k9",
  "venue": "Age and ageing",
  "versions": []
}