{
  "abstract": "I connect two literatures developed independently: the path-measure formulation of non-equilibrium statistical mechanics, where a trajectory action decomposes into a time-antisymmetric (entropic) and time-symmetric (frenetic) sector, and the stochastic modelling of ribosomal traffic on messenger RNA. The biological target is a proposed intervention -- antisense oligonucleotide (ASO) interference with wobble-uridine (U34) modification of transfer RNA -- whose intended effect is not to abolish translation but to perturb its timing, driving ribosome collisions and collision-triggered transcript decay preferentially on high-flux, codon-biased transcripts. Dynamical-activity and large-deviation analyses of generic lattice exclusion models -- notably the symmetric and totally asymmetric simple exclusion processes -- are well established. To my knowledge their formalization specifically for ribosomal traffic queues, translation elongation, and collision-triggered no-go decay remains unoccupied; this paper addresses that narrower gap, not the general one. Two claims here are load-bearing and untested. First, selectivity: transcripts whose loss is therapeutically desirable are separable, by vulnerable-codon-pair burden, from transcripts whose loss is toxic. Second, non-redundancy: the frenetic decomposition yields predictions, specific to ribosomal queueing and collision-triggered decay, not already obtainable from rate-level exclusion-process models or existing activity/large-deviation analyses of exclusion processes. This paper establishes neither. It specifies both as falsifiable tests with pre-registered decision rules, including outcomes under which the framework should be abandoned or narrowed. It is a research programme proposal, not a result. No new experimental, computational, or bioinformatic results are reported.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2609.25536",
  "author_total": 1,
  "authors": [
    {
      "name": "Shlomo Segal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7wb6ew0hre49n.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2609.25536",
  "fulltext_url": null,
  "id": "7wb6ew0hre49n",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2609.25536",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "cond-mat.stat-mech"
    ],
    [
      "openalex",
      "1312|RNA and protein synthesis mechanisms"
    ]
  ],
  "openalex": "W7214066254",
  "pdf_url": "https://arxiv.org/pdf/2609.25536",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7wb6ew0hre49n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:39Z",
      "native_id": "2609.25536",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2609.25536"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:cond-mat.stat-mech",
      "subfield": "statistical-nonlinear"
    }
  ],
  "title": "Kinetic Interference in Translational Control: A Path-Measure Framework for Collision-Triggered Transcript Decay",
  "title_text": "Kinetic Interference in Translational Control: A Path-Measure Framework for Collision-Triggered Transcript Decay",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:39Z",
  "url": "https://research.draconitic.com/paper/7wb6ew0hre49n",
  "venue": "arXiv",
  "versions": []
}