{
  "abstract": "Visual behavior requires coordinated activity across hierarchically organized brain circuits. Understanding this complexity demands datasets that are both large-scale (sampling many areas) and dense (recording many neurons in each area). Here we present a database of spiking activity across the mouse visual system-including thalamus, cortex, and midbrain-while mice perform an image change detection task. Using Neuropixels probes, we record from >75,000 high-quality units in 54 mice, mapping area-, cortical layer-, and cell type-specific coding of sensory and motor information. Modulation by task-engagement increased across the thalamocortical hierarchy but was strongest in the midbrain. Novel images modulated cortical (but not thalamic) responses through delayed recurrent activity. Population decoding and optogenetics identified a critical decision window for change detection and revealed that mice use an adaptation-based rather than image-comparison strategy. This comprehensive resource provides a valuable substrate for understanding sensorimotor computations in neural networks.",
  "abstract_shown": true,
  "affiliations": [
    "Allen Institute/Neural Dynamics, Seattle, WA 98109, USA",
    "Allen Institute",
    "Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA",
    "Department of Neuroscience, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY 10032, USA",
    "Allen Institute/Brain Health, Seattle, WA 98109, USA",
    "Allen Institute/Brain Science, Seattle, WA 98109, USA",
    "Allen Institute, Seattle, WA 98109, USA",
    "General Sense, Alachua, FL 32615, USA",
    "SIXTY D, Bend, OR 97702, USA",
    "University of Arizona College of Medicine, Tucson, AZ 85724, USA",
    "Allen Institute/Neural Dynamics, Seattle, WA 98109, USA. Electronic address: shawno@alleninstitute.org"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 49,
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    {
      "affs": [
        0,
        1
      ],
      "name": "Corbett Bennett",
      "orcid": "0009-0001-2847-7754"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Samuel D. Gale"
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    {
      "affs": [
        2,
        1
      ],
      "name": "Greggory R. Heller",
      "orcid": "0000-0003-3552-996X"
    },
    {
      "affs": [
        3,
        1
      ],
      "name": "Tamina K. Ramirez",
      "orcid": "0000-0002-6569-5291"
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        0,
        1
      ],
      "name": "Hannah Belski",
      "orcid": "0009-0001-5422-5964"
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        0,
        1
      ],
      "name": "Alex T. Piet",
      "orcid": "0000-0002-6529-1414"
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        1
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      "name": "Omid A. Zobeiri",
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        1
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      "name": "Adam Amster",
      "orcid": "0000-0002-5724-7472"
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        4,
        1
      ],
      "name": "Anton S. Arkhipov",
      "orcid": "0000-0003-1106-8310"
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    {
      "affs": [
        6,
        1
      ],
      "name": "Alex Cahoon"
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        1
      ],
      "name": "Shiella Caldejon",
      "orcid": "0009-0002-9734-5517"
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        1
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      "name": "Mikayla Carlson",
      "orcid": "0009-0003-7019-2781"
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    {
      "affs": [
        6,
        1
      ],
      "name": "Linzy Casal"
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    {
      "affs": [
        5,
        1
      ],
      "name": "Scott F. Daniel",
      "orcid": "0000-0001-8319-2359"
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    {
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        6,
        1
      ],
      "name": "Colin Farrell",
      "orcid": "0000-0003-3487-3064"
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    {
      "affs": [
        0,
        1
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      "name": "Marina Garrett",
      "orcid": "0000-0002-5271-2291"
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    {
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        1
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      "name": "Ryan Gillis",
      "orcid": "0009-0000-1879-6519"
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    {
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        1
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      "name": "Conor Grasso",
      "orcid": "0009-0003-6384-4075"
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    {
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        1
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      "name": "Ben Hardcastle",
      "orcid": "0000-0002-4819-5631"
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    {
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        1
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      "name": "Ross Hytnen"
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      "name": "Tye Johnson",
      "orcid": "0009-0006-7239-7571"
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        7,
        1
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      "name": "Peter Ledochowitsch",
      "orcid": "0000-0003-0835-3444"
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    {
      "affs": [
        6,
        1
      ],
      "name": "Quinn L’Heureux",
      "orcid": "0000-0002-3376-2031"
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    {
      "affs": [
        0,
        1
      ],
      "name": "Dana Mastrovito"
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    {
      "affs": [
        0,
        1
      ],
      "name": "Ethan G. McBride",
      "orcid": "0000-0001-9489-2828"
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    {
      "affs": [
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        1
      ],
      "name": "Ştefan Mihalaş",
      "orcid": "0000-0002-2629-7100"
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    {
      "affs": [
        6,
        1
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      "name": "Chris Mochizuki"
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      "affs": [
        5,
        1
      ],
      "name": "Christopher B. Morrison"
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    {
      "affs": [
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        1
      ],
      "name": "Chelsea Nayan"
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    {
      "affs": [
        5,
        1
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      "name": "Nhan-Kiet Ngo"
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    {
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        6,
        1
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      "name": "Kat North"
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      "name": "Douglas R. Ollerenshaw",
      "orcid": "0000-0002-3692-1835"
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        1
      ],
      "name": "Ben Ouellette",
      "orcid": "0000-0003-4913-554X"
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    {
      "affs": [
        6,
        1
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      "name": "Paul Rhoads"
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      "name": "Kara Ronellenfitch",
      "orcid": "0009-0007-6221-8485"
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    {
      "affs": [
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        1
      ],
      "name": "Martin Schroedter",
      "orcid": "0000-0002-0211-4226"
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        1
      ],
      "name": "Joshua H. Siegle",
      "orcid": "0000-0002-7736-4844"
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    {
      "affs": [
        6,
        1
      ],
      "name": "Cliff Slaughterbeck",
      "orcid": "0000-0003-2789-9071"
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    {
      "affs": [
        8,
        1
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      "name": "David Sullivan"
    },
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        0,
        1
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      "name": "Jackie Swapp",
      "orcid": "0009-0008-4965-6242"
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    {
      "affs": [
        5,
        1
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      "name": "Michael Taormina"
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    {
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        6,
        1
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      "name": "Wayne Wakeman",
      "orcid": "0000-0002-3693-3609"
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        9,
        1
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      "name": "Xana Waughman"
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        0,
        1
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      "name": "Allison Williford",
      "orcid": "0009-0000-7282-7515"
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    {
      "affs": [
        6,
        1
      ],
      "name": "John W. Phillips",
      "orcid": "0000-0003-1080-7556"
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    {
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        1
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      "name": "Peter A. Groblewski",
      "orcid": "0000-0002-8415-1118"
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        1
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      "name": "Séverine Durand",
      "orcid": "0000-0001-7788-0200"
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        1
      ],
      "name": "Christof Koch A",
      "orcid": "0000-0001-6482-8067"
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    {
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        10,
        1
      ],
      "name": "Shawn R. Olsen",
      "orcid": "0000-0002-9568-7057"
    }
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  "bibtex": "https://research.draconitic.com/paper/7wbqf16xk8mgr.bib",
  "cited_by": 9,
  "doi": "10.1016/j.cell.2026.06.025",
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  "id": "7wbqf16xk8mgr",
  "issns": [
    "0092-8674",
    "1097-4172"
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  "landing_url": "https://doi.org/10.1016/j.cell.2026.06.025",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2805|Visual perception and processing mechanisms"
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  "pdf_url": null,
  "pmcid": "PMC12632887",
  "pmid": "41278866",
  "published": "2026-07-01",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/7wbqf16xk8mgr.ris",
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      "url": "https://doi.org/10.1016/j.cell.2026.06.025"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Visual perception and processing mechanisms",
      "subfield": "neuroscience"
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  "title": "Map of spiking activity underlying change detection in the mouse visual system",
  "title_text": "Map of spiking activity underlying change detection in the mouse visual system",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:12Z",
  "url": "https://research.draconitic.com/paper/7wbqf16xk8mgr",
  "venue": "Cell",
  "versions": []
}