{
  "abstract": "BACKGROUND AND OBJECTIVES: We characterized fine-scale geographic variation in serum trace metals across Campania (southern Italy). MATERIALS AND METHODS: In 2016-2017, the SPES programme sampled residents aged 20-49 years from municipal registries across Campania. Municipalities were stratified using an environmental-pressure index into three broad impact strata: high-impact, medium-impact and low-impact. For higher spatial resolution, municipalities were also grouped into 21 predefined municipal clusters. We measured 20 serum trace metals by ICP-MS and estimated age- and sex-adjusted geometric mean ratios (GMRs) comparing each stratum or cluster with the study-wide geometric mean. RESULTS: Of 4205 enrolled participants, 4188 were included. Medium-impact areas showed higher mercury (GMR 1.87, 95% CI 1.73-2.02) and antimony (1.95, 1.71-2.23) relative to the cohort average. At the municipal-cluster scale, the Irno Valley clusters around the Fonderie Pisano foundry (Baronissi-Pellezzano and Salerno) had about six-fold higher mercury (GMR 5.71 and 6.10) and about three-fold higher antimony (3.45 and 2.93), whereas the Valle del Sabato cluster showed about ten-fold higher antimony (GMR 10.5) and about seven-fold higher nickel (7.16) and cadmium (7.67). CONCLUSIONS: Overall serum metal concentrations were broadly comparable with European general-population ranges, but pronounced small-area heterogeneity indicates localized hotspots that provincial or regional averages can obscure.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Public Health, University of Naples Federico II"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pellegrino Cerino",
      "orcid": "0009-0009-7944-239X"
    },
    {
      "affs": [
        0
      ],
      "name": "Antonio Pizzolante",
      "orcid": "0000-0002-5543-141X"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlo Buonerba",
      "orcid": "0000-0002-1806-442X"
    },
    {
      "affs": [
        0
      ],
      "name": "Paolo Montuori",
      "orcid": "0000-0002-8745-232X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7weh52v04j7hx.bib",
  "cited_by": 5,
  "doi": "10.1080/20565623.2026.2668083",
  "fulltext_url": null,
  "id": "7weh52v04j7hx",
  "issns": [
    "2056-5623"
  ],
  "landing_url": "https://doi.org/10.1080/20565623.2026.2668083",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
    ]
  ],
  "openalex": "W7165739003",
  "pdf_url": null,
  "pmcid": "PMC13313210",
  "pmid": "42338320",
  "published": "2026-06-24",
  "publisher": "Future Science Ltd",
  "ris": "https://research.draconitic.com/paper/7weh52v04j7hx.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T13:20:23Z",
      "native_id": "W7165739003",
      "source": "openalex",
      "url": "https://doi.org/10.1080/20565623.2026.2668083"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Heavy Metal Exposure and Toxicity",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Serum trace metals across environmental-pressure strata in Campania, Italy (SPES): a population-based cross-sectional biomonitoring study",
  "title_text": "Serum trace metals across environmental-pressure strata in Campania, Italy (SPES): a population-based cross-sectional biomonitoring study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:21:03Z",
  "url": "https://research.draconitic.com/paper/7weh52v04j7hx",
  "venue": "Future Science OA",
  "versions": []
}