{
  "abstract": "Primary hepatic neuroblastoma (PHN) is an exceptionally rare subtype of neuroblastoma. Neuroblastoma typically arises in tissues of the sympathetic nervous system, and hepatic metastases are more common than PHN. We present a 12-year-old male who presented with abdominal discomfort. Imaging revealed hepatomegaly with a solitary mass in segment V of the liver. After total resection, histopathological analysis identified a poorly differentiated neuroblastoma with a low mitotic-karyorrhectic index (<2%) and absence of neuroblastoma (MYCN) gene amplification (International Neuroblastoma Staging System, stage 1).\n\nThis case is notable for the patient's age, successful surgical outcome, and mass confinement of the liver. Despite poor cellular differentiation yielding an unfavorable histological grade, the localized Stage 1 disease and absence of MYCN amplification supported an individualized approach resulting in the absence of disease recurrence for 18 months postoperatively without chemotherapy. PHN should be considered in the differential diagnosis for children presenting with a solitary liver mass, regardless of age.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Paediatric Haematology-Oncology, Royal Medical Services - Queen Rania Children’s Hospital, Amman, JOR",
    "Department of Paediatric Radiology, Royal Medical Services - Queen Rania Children’s Hospital, Amman, JOR",
    "Department of Pathology and Laboratory Medicine, Royal Medical Services - Princess Iman Center for Research and Laboratory, Amman, JOR",
    "Department of Paediatric Surgery, Royal Medical Services - Queen Rania Children’s Hospital, Amman, JOR"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mais Jazazi"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruba Alhazaimeh"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayman Alhwayan"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohammed Alsmadi"
    },
    {
      "affs": [
        0
      ],
      "name": "Atwa Altawarh"
    },
    {
      "affs": [
        0
      ],
      "name": "Suliman Aljaafreh"
    },
    {
      "affs": [
        2
      ],
      "name": "Ruba Y Shannaq"
    },
    {
      "affs": [
        3
      ],
      "name": "Khaled Alshar"
    },
    {
      "affs": [
        0
      ],
      "name": "Maher Khader"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7wp7tehfwt26n.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.117304",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13723323/?tool=EBI",
  "id": "7wp7tehfwt26n",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13723323",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Oncology"
    ],
    [
      "heading",
      "Pediatric Surgery"
    ],
    [
      "heading",
      "Pediatrics"
    ],
    [
      "openalex",
      "2728|Neuroblastoma Research and Treatments"
    ]
  ],
  "openalex": "W7215130583",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13723323/pdf/?tool=EBI",
  "pmcid": "PMC13723323",
  "pmid": "42967129",
  "published": "2026-10-01",
  "publisher": "Cureus Inc.",
  "ris": "https://research.draconitic.com/paper/7wp7tehfwt26n.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:51Z",
      "native_id": "PMC:PMC13723323",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13723323"
    },
    {
      "first_seen": "2026-11-04T12:21:56Z",
      "native_id": "PMC13723323",
      "source": "pmc",
      "url": "https://doi.org/10.7759/cureus.117304"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Oncology",
      "subfield": "oncology"
    },
    {
      "field": "medicine",
      "origin": "heading:Pediatrics",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Primary Hepatic Neuroblastoma: A Case Report of a Solitary Liver Mass in an Adolescent Male",
  "title_text": "Primary Hepatic Neuroblastoma: A Case Report of a Solitary Liver Mass in an Adolescent Male",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:56Z",
  "url": "https://research.draconitic.com/paper/7wp7tehfwt26n",
  "venue": "Cureus",
  "versions": []
}