{
  "abstract": "Human tissues and organs exhibit limited regenerative capacity; thus, tissue engineering (TE) and regenerative medicine aim to repair damaged tissues and restore their function. TE achieves in situ tissue regeneration through the integration of cells, biomaterial scaffolds, and signaling molecules. Electrospun nanofibers serve as ideal TE scaffolds due to their large surface area and porosity. Aligned electrospun fiber (AESF) scaffolds are used as stem cell carriers for tissue reconstruction because of their extracellular matrix mimetic structures of anisotropic tissues, such as nerves and tendons. Stem cells are the preferred seed cells for TE due to their multidirectional differentiation, microenvironmental regulation, and paracrine cytokine production abilities. This review outlines the aligned electrospinning principles, parameters, strategies, and material selection for stem cell-assisted AESF scaffolds. Following, the types of stem cells, strategies for incorporating stem cells into scaffolds, and the mechanisms by which AESFs regulate stem cell behavior are briefly described. Finally, applications of stem cell-assisted AESF scaffolds in TE are explored. The review concludes by emerging applications of stem cell-assisted AESF scaffolds in TE, discussing current limitations, and potential future directions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China.",
    "Shantou Plastic Surgery Clinical Research Center, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515041, Guangdong, China.",
    "Department of Dermatology, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China.",
    "Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, 515031, China. bo.liu@ccelab.com.cn.",
    "Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China. 02wczhang@stu.edu.cn.",
    "Shantou Plastic Surgery Clinical Research Center, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515041, Guangdong, China. 02wczhang@stu.edu.cn.",
    "Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China. sjtang3@stu.edu.cn.",
    "Shantou Plastic Surgery Clinical Research Center, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515041, Guangdong, China. sjtang3@stu.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huanmei Jing"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Na Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yaomu Jiang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Liyun Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Min Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jinxian Wu"
    },
    {
      "affs": [
        3
      ],
      "name": "Bo Liu"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Wancong Zhang"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Shijie Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7wpx6jcb011y8.bib",
  "cited_by": 0,
  "doi": "10.1186/s13287-026-05201-3",
  "fulltext_url": "https://europepmc.org/articles/PMC13729365",
  "id": "7wpx6jcb011y8",
  "issns": [
    "1757-6512"
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  "landing_url": "https://europepmc.org/article/MED/42972423",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "lcc",
      "QD415-436"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2502|Electrospun Nanofibers in Biomedical Applications"
    ]
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  "openalex": "W7172508316",
  "pdf_url": "https://europepmc.org/articles/PMC13729365?pdf=render",
  "pmcid": "PMC13729365",
  "pmid": "42972423",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7wpx6jcb011y8.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42972423",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972423"
    },
    {
      "first_seen": "2026-11-07T12:22:08Z",
      "native_id": "PMC13729365",
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      "url": "https://doi.org/10.1186/s13287-026-05201-3"
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    {
      "first_seen": "2026-11-08T14:20:55Z",
      "native_id": "03609002c88f475cbf21d4e8c8c563c5",
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  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Electrospun Nanofibers in Biomedical Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Stem cell-assisted aligned electrospun nanofiber scaffold for tissue engineering: development to application.",
  "title_text": "Stem cell-assisted aligned electrospun nanofiber scaffold for tissue engineering: development to application.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T14:21:15Z",
  "url": "https://research.draconitic.com/paper/7wpx6jcb011y8",
  "venue": "Stem cell research & therapy",
  "versions": []
}