{
  "abstract": "Introduction\n\nMetabolic dysregulation is a hallmark of Alzheimer's disease (AD), with numerous studies characterizing metabolic pathways associated with AD onset and progression. A limitation of these studies has been a focus on non-Hispanic white participants. Despite evidence that AD prevalence, progression, and biomarkers differ across ethnoracial groups, it remains unclear whether previously identified metabolic dysregulation in AD brains generalizes across populations.Methods\n\nWe analyzed metabolomics data from 547 postmortem brain tissue samples of Hispanic American, Non-Hispanic African American, and White subjects, providing the largest multiethnic AD brain cohort to date. A metabolome-wide association study examined how relationships between metabolite abundance and AD neuropathology varied by ethnoracial group.Results\n\nForty-eight metabolites exhibited significant heterogeneity with tau pathology (Braak stage), with enrichment in tricarboxylic-acid-cycle intermediates and sphingolipid-ceramide pathway lipids, and with metabolite-tau associations driven predominantly by the Hispanic American and non-Hispanic White groups.Discussion\n\nThese findings reveal ethnoracial-specific metabolic signatures of tau pathology and emphasize the need to evaluate emerging therapeutic targets across diverse groups.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA.",
    "Buck Institute for Research on Aging, Novato, California, USA.",
    "Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.",
    "Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, Victoria, Australia.",
    "Department of Psychiatry and Behavioral Sciences, Duke Institute for Brain Sciences and Department of Medicine, Duke University, Durham, North Carolina, USA.",
    "Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.",
    "Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.",
    "Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.",
    "Center for Translational and Computational Neuroimmunology, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.",
    "Sage Bionetworks, Seattle, Washington, USA.",
    "Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.",
    "Department of Biochemistry, Emory University, Atlanta, Georgia, USA.",
    "Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.",
    "Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Annalise Schweickart",
      "orcid": "0000-0001-9691-3741"
    },
    {
      "affs": [
        0
      ],
      "name": "Richa Batra"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kevin Huynh"
    },
    {
      "affs": [
        4
      ],
      "name": "Collette Blach"
    },
    {
      "affs": [
        4
      ],
      "name": "Alexandra Kueider-Paisley"
    },
    {
      "affs": [
        5
      ],
      "name": "Joseph S Reddy"
    },
    {
      "affs": [
        6
      ],
      "name": "David A Bennett"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Peter J Meikle"
    },
    {
      "affs": [
        7
      ],
      "name": "Bin Zhang"
    },
    {
      "affs": [
        8
      ],
      "name": "Philip L De Jager"
    },
    {
      "affs": [
        9
      ],
      "name": "Laura Heath"
    },
    {
      "affs": [
        9
      ],
      "name": "Jaclyn Beck"
    },
    {
      "affs": [
        9
      ],
      "name": "Jo Scanlan"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Nicholas T Seyfried"
    },
    {
      "affs": [
        5
      ],
      "name": "Dennis W Dickson"
    },
    {
      "affs": [
        5,
        12
      ],
      "name": "Nilüfer Ertekin-Taner"
    },
    {
      "name": "Alzheimer's Disease Metabolomics Consortium"
    },
    {
      "affs": [
        4
      ],
      "name": "Rima Kaddurah-Daouk"
    },
    {
      "affs": [
        4,
        13
      ],
      "name": "Matthias Arnold"
    },
    {
      "affs": [
        0
      ],
      "name": "Jan Krumsiek",
      "orcid": "0000-0003-4734-3791"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7x93jhaz89gmj.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71690",
  "fulltext_url": "https://europepmc.org/articles/PMC13661748",
  "id": "7x93jhaz89gmj",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://europepmc.org/article/MED/42869853",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7221625308",
  "pdf_url": "https://europepmc.org/articles/PMC13661748?pdf=render",
  "pmcid": "PMC13661748",
  "pmid": "42869853",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7x93jhaz89gmj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42869853",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42869853"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.",
  "title_text": "Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/7x93jhaz89gmj",
  "venue": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
  "versions": []
}