{
  "abstract": "Background/Aims: This study aimed to investigate whether delayed gastric emptying (GE) is associated with progression to end-stage renal disease (ESRD) in diabetic patients with chronic upper gastrointestinal (UGI) symptoms.\n\nMethods: We extracted data on demographics, UGI symptoms, GE study, and renal outcome from the medical records of diabetic patients with chronic UGI symptoms who underwent a GE study over 17 years. Renal outcome was defined as the development of ESRD. An association between delayed GE and renal outcome was investigated using a Cox proportional hazards regression model with Firth’s correction.\n\nResults: Among 515 subjects who had undergone a GE study, 100 patients with type 1 or type 2 diabetes (67 females, 85 with type 2 diabetes, median age 63 years) were included. Of the 100 patients, 53 had delayed GE. During the follow-up (median, 264 weeks), 25 patients with diabetes developed ESRD. The Firth-penalized Cox regression model showed that delayed GE was significantly associated with renal outcome in diabetic patients with chronic UGI symptoms (hazard ratio 3.12; 95% confidence interval 1.34–7.97; P = 0.008). The 5-year cumulative incidence of renal outcome was approximately 9% in patients with normal GE and 35% in those with delayed GE (log-rank P = 0.021).\n\nConclusions: Delayed GE was associated with progression to ESRD in diabetic patients with chronic UGI symptoms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Chonnam National University Medical School Gwangju Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jin Ook Chung",
      "orcid": "0000-0001-8084-0752"
    },
    {
      "affs": [
        0
      ],
      "name": "Seon-Young Park",
      "orcid": "0000-0002-0962-5977"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyun-Soo Kim",
      "orcid": "0000-0003-4834-0496"
    },
    {
      "affs": [
        0
      ],
      "name": "Dong Jin Chung",
      "orcid": "0000-0001-6562-2175"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7y5be36jyrz39.bib",
  "cited_by": 0,
  "doi": "10.5056/jnm25188",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725380/",
  "id": "7y5be36jyrz39",
  "issns": [
    "2093-0879",
    "2093-0887"
  ],
  "landing_url": "https://doi.org/10.5056/jnm25188",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2715|Gastrointestinal motility and disorders"
    ]
  ],
  "openalex": "W7224274180",
  "pdf_url": "https://www.jnmjournal.org/journal/download_pdf.php?doi=10.5056/jnm25188",
  "pmcid": "PMC13725380",
  "pmid": "42954008",
  "published": "2026-10-31",
  "publisher": "The Korean Society of Neurogastroenterology and Motility",
  "ris": "https://research.draconitic.com/paper/7y5be36jyrz39.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:47Z",
      "native_id": "PMC13725380",
      "source": "pmc",
      "url": "https://doi.org/10.5056/jnm25188"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastrointestinal motility and disorders",
      "subfield": "general"
    }
  ],
  "title": "Delayed Gastric Emptying Is Associated With Progression to End-Stage Renal Disease in Diabetic Patients With Chronic Upper Gastrointestinal Symptoms",
  "title_text": "Delayed Gastric Emptying Is Associated With Progression to End-Stage Renal Disease in Diabetic Patients With Chronic Upper Gastrointestinal Symptoms",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:39Z",
  "url": "https://research.draconitic.com/paper/7y5be36jyrz39",
  "venue": "Journal of Neurogastroenterology and Motility",
  "versions": []
}