{
  "abstract": "The global burden of prostate cancer continues to rise, yet conventional biomarkers and therapies face substantial limitations due to tumor heterogeneity and treatment resistance. The gut microbiome has emerged as a critical regulator of host metabolism and immunity, with its bioactive metabolites influencing prostate cancer pathogenesis through multiple interconnected pathways. Short-chain fatty acids, secondary bile acids, microbiota-modulated tryptophan metabolites, and microbiota-derived androgens modulate immune surveillance, androgen metabolism, and therapeutic responses via hormonal and inflammatory signaling networks. These metabolites exert context-dependent effects that vary with concentration, disease stage, and the tumor microenvironment. This narrative review comprehensively synthesizes current mechanistic evidence on microbiome-derived metabolite signaling and evaluates the potential of circulating microbial metabolites as non-invasive biomarkers, while outlining future research priorities for clinical translation in prostate cancer management.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Jun Mi"
    },
    {
      "name": "Peilong Wang"
    },
    {
      "name": "Fang Wu"
    },
    {
      "name": "Xi Xiao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7ya35jcgcarvd.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.1982639",
  "fulltext_url": null,
  "id": "7ya35jcgcarvd",
  "issns": [
    "1664-302X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1982639",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "biology/microbiology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7ya35jcgcarvd.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:43Z",
      "native_id": "10.3389/fmicb.2026.1982639",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1982639"
    },
    {
      "first_seen": "2026-11-07T00:21:16Z",
      "native_id": "10.3389/fmicb.2026.1982639",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1982639/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "feed-journal:biology/microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Gut microbiome-derived metabolites in prostate cancer: microbial mechanisms of immune modulation, androgen metabolism, and therapeutic implications",
  "title_text": "Gut microbiome-derived metabolites in prostate cancer: microbial mechanisms of immune modulation, androgen metabolism, and therapeutic implications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:22:41Z",
  "url": "https://research.draconitic.com/paper/7ya35jcgcarvd",
  "venue": "Frontiers in Microbiology",
  "versions": []
}