{
  "abstract": "PLK1 is a highly conserved serine/threonine kinase that plays a central role in mitosis and cell-cycle progression. PLK1 is dynamically regulated by multiple post-translational modifications (PTMs), which coordinate its kinase activity, protein stability, subcellular localization, and protein–protein interactions, thereby ensuring its precise functions during cell-cycle progression and tumor progression. Despite substantial advances in understanding the post-translational regulation of PLK1, how different PTMs interact and coordinately regulate PLK1 remains incompletely understood. In this review, we systematically summarize the major PTMs of PLK1 and the molecular mechanisms through which they regulate PLK1 function, with particular emphasis on their roles in cell-cycle regulation and tumor progression. Beyond discussing individual PTMs, we integrate emerging evidence for crosstalk among different modifications, highlighting their cooperative, antagonistic, and sequential regulatory relationships and providing an integrated perspective on the dynamic post-translational regulation of PLK1. Finally, we discuss the biological significance of PLK1 PTM crosstalk, key unresolved questions in the field, and its potential implications for future cancer research and PLK1-targeted strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Clinical Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, China",
    "Clinical Laboratory, Jinan Children’s Hospital, Jinan, China",
    "Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenjing Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Wenjing Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Huiping Lin"
    },
    {
      "affs": [
        2
      ],
      "name": "Donghua Wen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7yh61r2kcqsvw.bib",
  "cited_by": 0,
  "doi": "10.3389/fcell.2026.1987587",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fcell.2026.1987587/full",
  "id": "7yh61r2kcqsvw",
  "issns": [
    "2296-634X"
  ],
  "landing_url": "https://doi.org/10.3389/fcell.2026.1987587",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "1307|Microtubule and mitosis dynamics"
    ]
  ],
  "openalex": "W7223392390",
  "pdf_url": "https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1987587/pdf",
  "pmcid": "PMC13740389",
  "pmid": "42996787",
  "published": "2026-10-23",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/7yh61r2kcqsvw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:02Z",
      "native_id": "ff02c923cdbd4023849fb61c93c21182",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fcell.2026.1987587"
    },
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42996787",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996787"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Microtubule and mitosis dynamics",
      "subfield": "cell-biology"
    }
  ],
  "title": "Post-translational modifications of PLK1: a dynamic regulatory network in cell cycle regulation and tumor progression",
  "title_text": "Post-translational modifications of PLK1: a dynamic regulatory network in cell cycle regulation and tumor progression",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/7yh61r2kcqsvw",
  "venue": "Frontiers in Cell and Developmental Biology",
  "versions": []
}